Rate of breast biopsy referrals in female BRCA mutation carriers aged 50 years or more: a retrospective comparative study and matched analysis.
BRCA
Biopsy
Breast cancer
High risk
Screening
Journal
Breast cancer research and treatment
ISSN: 1573-7217
Titre abrégé: Breast Cancer Res Treat
Pays: Netherlands
ID NLM: 8111104
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
25
08
2021
accepted:
20
12
2021
pubmed:
9
4
2022
medline:
14
5
2022
entrez:
8
4
2022
Statut:
ppublish
Résumé
To evaluate the total biopsy and positive biopsy rates in women at high risk of breast cancer compared to the general population. The study group consisted of 330 women with pathogenic variants (PVs) in BRCA1/2 attending the dedicated multidisciplinary breast cancer clinic of a tertiary medical center in Israel. Clinical, genetic, and biopsy data were retrieved from the central healthcare database and the medical files. Patients aged 50 years or older during follow-up were matched 1:10 to women in the general population referred for routine breast cancer screening at the same age, as recommended by international guidelines. The groups were compared for rate of biopsy studies performed and percentage of positive biopsy results. Matched analysis was performed to correct for confounders. The total biopsy rate per 1000 follow-up years was 61.7 in the study group and 22.7 in the control group (p < 0.001). The corresponding positive biopsy rates per 1000 follow-up years were 26.4 and 2.0 (p < 0.001), and the positive biopsy percentages, 42.9% and 8.7% (p < 0.0001). Women aged 50 + years with PVs in BRCA1/2 attending a dedicated clinic have a 2.7 times higher biopsy rate per 1000 follow-up years, a 13.2 times higher positive biopsy rate per 1000 follow-up years, and a 4.9 times higher positive biopsy percentage than same-aged women in the general population.
Identifiants
pubmed: 35391652
doi: 10.1007/s10549-021-06498-9
pii: 10.1007/s10549-021-06498-9
pmc: PMC9090689
doi:
Substances chimiques
BRCA1 Protein
0
BRCA2 Protein
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
507-514Informations de copyright
© 2022. The Author(s).
Références
Ann Surg Oncol. 2021 Aug;28(8):4306-4317
pubmed: 33398646
Breast Care (Basel). 2020 Jun;15(3):253-259
pubmed: 32774219
J Psychosoc Oncol. 2021;39(5):646-672
pubmed: 33089755
JAMA Intern Med. 2018 Apr 1;178(4):458-468
pubmed: 29435556
Isr Med Assoc J. 2016 Sep;18(9):549-552
pubmed: 28471604
CA Cancer J Clin. 2009 Sep-Oct;59(5):290-302
pubmed: 19679690
JAMA. 2015 Oct 20;314(15):1615-34
pubmed: 26501537
Clin Breast Cancer. 2018 Aug;18(4):e695-e698
pubmed: 29292184
Clin Radiol. 2019 May;74(5):384-389
pubmed: 30799096
Genet Med. 2017 Jul;19(7):754-762
pubmed: 27929526
J Clin Oncol. 2020 Nov 20;38(33):3874-3882
pubmed: 32931396
Cancer Epidemiol Biomarkers Prev. 2004 Dec;13(12):2078-83
pubmed: 15598764
Clin Obstet Gynecol. 2011 Mar;54(1):96-102
pubmed: 21278508
CA Cancer J Clin. 2011 Mar-Apr;61(2):69-90
pubmed: 21296855
J Natl Compr Canc Netw. 2021 Jan 06;19(1):77-102
pubmed: 33406487
Radiol Clin North Am. 2021 Jan;59(1):129-138
pubmed: 33222994
Nat Genet. 1996 Oct;14(2):185-7
pubmed: 8841191
Expert Rev Med Devices. 2019 May;16(5):351-362
pubmed: 30999781
J Immigr Minor Health. 2014 Oct;16(5):1007-10
pubmed: 23584710