Child Neurology: A Case Series of Heterogeneous Neuropsychiatric Symptoms and Outcome in Very Early-Onset Narcolepsy Type 1.

Cataplexy / diagnosis Child Disorders of Excessive Somnolence / diagnosis Humans Narcolepsy / diagnosis Neurology Quality of Life

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
07 06 2022
Historique:
received: 12 08 2021
accepted: 16 03 2022
pubmed: 8 4 2022
medline: 9 6 2022
entrez: 7 4 2022
Statut: ppublish

Résumé

Narcolepsy type 1 is a central disorder of hypersomnolence characterized by excessive daytime sleepiness, cataplexy (i.e., sudden loss of muscle tone during wakefulness triggered by emotions), and REM sleep-related manifestations that can present with a peculiar phenotype when arising at a pediatric age. Several features of childhood-onset narcolepsy type 1 are also common in neuropsychiatric conditions; discrete neuropsychiatric comorbidity has also been demonstrated. Here, we report on 3 children with very early narcolepsy type 1. All 3 patients had psychiatric features at the time of symptom onset coupled with peculiar motor disturbances. The course of narcolepsy symptoms also paralleled neuropsychiatric symptoms, suggesting a possible intrinsic link between sleep and psychological features. Multidisciplinary management is mandatory for pediatric narcolepsy type 1 since prompt disease management addressing neuropsychiatric symptoms could lead to better clinical outcomes and quality of life.

Identifiants

DOI: 10.1212/WNL.0000000000200666 PMID: 35387850
pubmed: 35387850
pii: WNL.0000000000200666
doi: 10.1212/WNL.0000000000200666
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

984-989

Informations de copyright

© 2022 American Academy of Neurology.

Auteurs

Marco Veneruso (M)

From the Department of Neurosciences (M.V., L.N.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova; IRCCS Istituto Delle Scienze Neurologiche di Bologna (M.V., F.P., D., G.P.); Department of Biomedical and Neuromotor Sciences (F.P., G.A., D.), University of Bologna; Department of Rehabilitation, Child and Adolescent Neuropsychiatry Unit (E.F.), ULSS 6, Vicenza; Department of Basic Medicine (M.F.), Neuroscience and Sense Organs, University Aldo Moro Bari; Center for Neurodegenerative Diseases and the Aging Brain (M.F.), University of Bari Aldo Moro -A.O. Pia Fondazione Cardinale G. Panico, Tricase; Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Child Neuropsychiatry Unit (L.N.), IRCCS Istituto G. Gaslini, Genova; Department of Medical and Surgical Sciences (A.C., A.P.), University of Bologna; IRCCS S.Orsola-Malpighi Hospital (A.C., A.P.); and Department of Biomedical (G.P.), Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
ORCID: 0000-0002-4293-0260

Fabio Pizza (F)

From the Department of Neurosciences (M.V., L.N.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova; IRCCS Istituto Delle Scienze Neurologiche di Bologna (M.V., F.P., D., G.P.); Department of Biomedical and Neuromotor Sciences (F.P., G.A., D.), University of Bologna; Department of Rehabilitation, Child and Adolescent Neuropsychiatry Unit (E.F.), ULSS 6, Vicenza; Department of Basic Medicine (M.F.), Neuroscience and Sense Organs, University Aldo Moro Bari; Center for Neurodegenerative Diseases and the Aging Brain (M.F.), University of Bari Aldo Moro -A.O. Pia Fondazione Cardinale G. Panico, Tricase; Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Child Neuropsychiatry Unit (L.N.), IRCCS Istituto G. Gaslini, Genova; Department of Medical and Surgical Sciences (A.C., A.P.), University of Bologna; IRCCS S.Orsola-Malpighi Hospital (A.C., A.P.); and Department of Biomedical (G.P.), Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Elena Finotti (E)

From the Department of Neurosciences (M.V., L.N.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova; IRCCS Istituto Delle Scienze Neurologiche di Bologna (M.V., F.P., D., G.P.); Department of Biomedical and Neuromotor Sciences (F.P., G.A., D.), University of Bologna; Department of Rehabilitation, Child and Adolescent Neuropsychiatry Unit (E.F.), ULSS 6, Vicenza; Department of Basic Medicine (M.F.), Neuroscience and Sense Organs, University Aldo Moro Bari; Center for Neurodegenerative Diseases and the Aging Brain (M.F.), University of Bari Aldo Moro -A.O. Pia Fondazione Cardinale G. Panico, Tricase; Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Child Neuropsychiatry Unit (L.N.), IRCCS Istituto G. Gaslini, Genova; Department of Medical and Surgical Sciences (A.C., A.P.), University of Bologna; IRCCS S.Orsola-Malpighi Hospital (A.C., A.P.); and Department of Biomedical (G.P.), Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Giulia Amore (G)

From the Department of Neurosciences (M.V., L.N.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova; IRCCS Istituto Delle Scienze Neurologiche di Bologna (M.V., F.P., D., G.P.); Department of Biomedical and Neuromotor Sciences (F.P., G.A., D.), University of Bologna; Department of Rehabilitation, Child and Adolescent Neuropsychiatry Unit (E.F.), ULSS 6, Vicenza; Department of Basic Medicine (M.F.), Neuroscience and Sense Organs, University Aldo Moro Bari; Center for Neurodegenerative Diseases and the Aging Brain (M.F.), University of Bari Aldo Moro -A.O. Pia Fondazione Cardinale G. Panico, Tricase; Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Child Neuropsychiatry Unit (L.N.), IRCCS Istituto G. Gaslini, Genova; Department of Medical and Surgical Sciences (A.C., A.P.), University of Bologna; IRCCS S.Orsola-Malpighi Hospital (A.C., A.P.); and Department of Biomedical (G.P.), Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Stefano Vandi (S)

From the Department of Neurosciences (M.V., L.N.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova; IRCCS Istituto Delle Scienze Neurologiche di Bologna (M.V., F.P., D., G.P.); Department of Biomedical and Neuromotor Sciences (F.P., G.A., D.), University of Bologna; Department of Rehabilitation, Child and Adolescent Neuropsychiatry Unit (E.F.), ULSS 6, Vicenza; Department of Basic Medicine (M.F.), Neuroscience and Sense Organs, University Aldo Moro Bari; Center for Neurodegenerative Diseases and the Aging Brain (M.F.), University of Bari Aldo Moro -A.O. Pia Fondazione Cardinale G. Panico, Tricase; Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Child Neuropsychiatry Unit (L.N.), IRCCS Istituto G. Gaslini, Genova; Department of Medical and Surgical Sciences (A.C., A.P.), University of Bologna; IRCCS S.Orsola-Malpighi Hospital (A.C., A.P.); and Department of Biomedical (G.P.), Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Marco Filardi (M)

From the Department of Neurosciences (M.V., L.N.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova; IRCCS Istituto Delle Scienze Neurologiche di Bologna (M.V., F.P., D., G.P.); Department of Biomedical and Neuromotor Sciences (F.P., G.A., D.), University of Bologna; Department of Rehabilitation, Child and Adolescent Neuropsychiatry Unit (E.F.), ULSS 6, Vicenza; Department of Basic Medicine (M.F.), Neuroscience and Sense Organs, University Aldo Moro Bari; Center for Neurodegenerative Diseases and the Aging Brain (M.F.), University of Bari Aldo Moro -A.O. Pia Fondazione Cardinale G. Panico, Tricase; Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Child Neuropsychiatry Unit (L.N.), IRCCS Istituto G. Gaslini, Genova; Department of Medical and Surgical Sciences (A.C., A.P.), University of Bologna; IRCCS S.Orsola-Malpighi Hospital (A.C., A.P.); and Department of Biomedical (G.P.), Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
ORCID: 0000-0001-9702-8314

Elena Antelmi (E)

From the Department of Neurosciences (M.V., L.N.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova; IRCCS Istituto Delle Scienze Neurologiche di Bologna (M.V., F.P., D., G.P.); Department of Biomedical and Neuromotor Sciences (F.P., G.A., D.), University of Bologna; Department of Rehabilitation, Child and Adolescent Neuropsychiatry Unit (E.F.), ULSS 6, Vicenza; Department of Basic Medicine (M.F.), Neuroscience and Sense Organs, University Aldo Moro Bari; Center for Neurodegenerative Diseases and the Aging Brain (M.F.), University of Bari Aldo Moro -A.O. Pia Fondazione Cardinale G. Panico, Tricase; Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Child Neuropsychiatry Unit (L.N.), IRCCS Istituto G. Gaslini, Genova; Department of Medical and Surgical Sciences (A.C., A.P.), University of Bologna; IRCCS S.Orsola-Malpighi Hospital (A.C., A.P.); and Department of Biomedical (G.P.), Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Lino Nobili (L)

From the Department of Neurosciences (M.V., L.N.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova; IRCCS Istituto Delle Scienze Neurologiche di Bologna (M.V., F.P., D., G.P.); Department of Biomedical and Neuromotor Sciences (F.P., G.A., D.), University of Bologna; Department of Rehabilitation, Child and Adolescent Neuropsychiatry Unit (E.F.), ULSS 6, Vicenza; Department of Basic Medicine (M.F.), Neuroscience and Sense Organs, University Aldo Moro Bari; Center for Neurodegenerative Diseases and the Aging Brain (M.F.), University of Bari Aldo Moro -A.O. Pia Fondazione Cardinale G. Panico, Tricase; Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Child Neuropsychiatry Unit (L.N.), IRCCS Istituto G. Gaslini, Genova; Department of Medical and Surgical Sciences (A.C., A.P.), University of Bologna; IRCCS S.Orsola-Malpighi Hospital (A.C., A.P.); and Department of Biomedical (G.P.), Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.
ORCID: 0000-0001-9317-5405

Alessandra Cassio (A)

From the Department of Neurosciences (M.V., L.N.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova; IRCCS Istituto Delle Scienze Neurologiche di Bologna (M.V., F.P., D., G.P.); Department of Biomedical and Neuromotor Sciences (F.P., G.A., D.), University of Bologna; Department of Rehabilitation, Child and Adolescent Neuropsychiatry Unit (E.F.), ULSS 6, Vicenza; Department of Basic Medicine (M.F.), Neuroscience and Sense Organs, University Aldo Moro Bari; Center for Neurodegenerative Diseases and the Aging Brain (M.F.), University of Bari Aldo Moro -A.O. Pia Fondazione Cardinale G. Panico, Tricase; Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Child Neuropsychiatry Unit (L.N.), IRCCS Istituto G. Gaslini, Genova; Department of Medical and Surgical Sciences (A.C., A.P.), University of Bologna; IRCCS S.Orsola-Malpighi Hospital (A.C., A.P.); and Department of Biomedical (G.P.), Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Andrea Pession (A)

From the Department of Neurosciences (M.V., L.N.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova; IRCCS Istituto Delle Scienze Neurologiche di Bologna (M.V., F.P., D., G.P.); Department of Biomedical and Neuromotor Sciences (F.P., G.A., D.), University of Bologna; Department of Rehabilitation, Child and Adolescent Neuropsychiatry Unit (E.F.), ULSS 6, Vicenza; Department of Basic Medicine (M.F.), Neuroscience and Sense Organs, University Aldo Moro Bari; Center for Neurodegenerative Diseases and the Aging Brain (M.F.), University of Bari Aldo Moro -A.O. Pia Fondazione Cardinale G. Panico, Tricase; Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Child Neuropsychiatry Unit (L.N.), IRCCS Istituto G. Gaslini, Genova; Department of Medical and Surgical Sciences (A.C., A.P.), University of Bologna; IRCCS S.Orsola-Malpighi Hospital (A.C., A.P.); and Department of Biomedical (G.P.), Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy.

Giuseppe Plazzi (G)

From the Department of Neurosciences (M.V., L.N.), Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova; IRCCS Istituto Delle Scienze Neurologiche di Bologna (M.V., F.P., D., G.P.); Department of Biomedical and Neuromotor Sciences (F.P., G.A., D.), University of Bologna; Department of Rehabilitation, Child and Adolescent Neuropsychiatry Unit (E.F.), ULSS 6, Vicenza; Department of Basic Medicine (M.F.), Neuroscience and Sense Organs, University Aldo Moro Bari; Center for Neurodegenerative Diseases and the Aging Brain (M.F.), University of Bari Aldo Moro -A.O. Pia Fondazione Cardinale G. Panico, Tricase; Neurology Unit (E.A.), Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona; Child Neuropsychiatry Unit (L.N.), IRCCS Istituto G. Gaslini, Genova; Department of Medical and Surgical Sciences (A.C., A.P.), University of Bologna; IRCCS S.Orsola-Malpighi Hospital (A.C., A.P.); and Department of Biomedical (G.P.), Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Modena, Italy. giuseppe.plazzi@isnb.it.

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Classifications MeSH

Recherchemedicale.com › Troubles mentaux › Troubles de la veille et du sommeil › Dyssomnies › Troubles du sommeil d'origine intrinsèque › Troubles du sommeil par somnolence excessive › Narcolepsie › Cataplexie › Child Neurology: A Case Series of...
Recherchemedicale.com › Personnes › Tranches d'âge › Enfant › Child Neurology: A Case Series of...
Recherchemedicale.com › Troubles mentaux › Troubles de la veille et du sommeil › Dyssomnies › Troubles du sommeil d'origine intrinsèque › Troubles du sommeil par somnolence excessive › Child Neurology: A Case Series of...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Child Neurology: A Case Series of...
Recherchemedicale.com › Troubles mentaux › Troubles de la veille et du sommeil › Dyssomnies › Troubles du sommeil d'origine intrinsèque › Troubles du sommeil par somnolence excessive › Narcolepsie › Child Neurology: A Case Series of...
Recherchemedicale.com › Professions de santé › Médecine › Neurologie › Child Neurology: A Case Series of...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Child Neurology: A Case Series of...