4'-Nitrobiphenyl thioglucoside as the Smallest, fluorescent photosensitizer with cancer targeting ligand.
Biphenyl
Glucose Transporter
Photodynamic Therapy
Photosensitizer
Journal
Bioorganic & medicinal chemistry
ISSN: 1464-3391
Titre abrégé: Bioorg Med Chem
Pays: England
ID NLM: 9413298
Informations de publication
Date de publication:
01 05 2022
01 05 2022
Historique:
received:
14
02
2022
revised:
28
03
2022
accepted:
28
03
2022
pubmed:
7
4
2022
medline:
3
5
2022
entrez:
6
4
2022
Statut:
ppublish
Résumé
We have previously developed a glucose-linked biphenyl photosensitizer that can pass through glucose transporters, aiming for cancer-selective photodynamic therapy (PDT). Its small size (MW: 435) will allow oral administration and a fast clearance avoiding photosensitivity. However, its fluorescence efficiency was quite low, causing difficulty in monitoring cellular uptake. We thus synthesized a series of monosaccharide-linked biphenyl derivatives with a sulfur atom replacing an oxygen atom, in search of a photosensitizer with a brighter fluorescence. Among them, 4'-nitrobiphenyl thioglucoside showed a fluorescence emission extending to near infra-red region with a strength three times greater than that of the previous compound. This compound was found to have a higher
Identifiants
pubmed: 35382968
pii: S0968-0896(22)00129-8
doi: 10.1016/j.bmc.2022.116737
pii:
doi:
Substances chimiques
Coloring Agents
0
Ligands
0
Photosensitizing Agents
0
Thioglucosides
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
116737Informations de copyright
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