Sea anemone Bartholomea annulata venom inhibits voltage-gated Na

Animals Cnidarian Venoms / pharmacology Mammals Receptors, GABA-A Sea Anemones / physiology gamma-Aminobutyric Acid

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
30 03 2022
Historique:
received: 28 10 2021
accepted: 17 03 2022
entrez: 31 3 2022
pubmed: 1 4 2022
medline: 2 4 2022
Statut: epublish

Résumé

Toxin production in nematocysts by Cnidaria phylum represents an important source of bioactive compounds. Using electrophysiology and, heterologous expression of mammalian ion channels in the Xenopus oocyte membrane, we identified two main effects produced by the sea anemone Bartholomea annulata venom. Nematocysts isolation and controlled discharge of their content, revealed that venom had potent effects on both voltage-dependent Na

Identifiants

DOI: 10.1038/s41598-022-09339-x PMID: 35354863 PMC: PMC8967859
pubmed: 35354863
doi: 10.1038/s41598-022-09339-x
pii: 10.1038/s41598-022-09339-x
pmc: PMC8967859
doi:

Substances chimiques

Cnidarian Venoms 0
Receptors, GABA-A 0
gamma-Aminobutyric Acid 56-12-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

5352

Informations de copyright

© 2022. The Author(s).

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Auteurs

Antònia Colom-Casasnovas (A)

Posgrado en Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, C.P. 04510, Coyoacán, Mexico, Mexico.
Unidad Académica de Sistemas Arrecifales Puerto Morelos, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Prolongación Niños Héroes s/n, Domicilio Conocido, C.P. 77580, Puerto Morelos, Quintana Roo, Mexico.

Edith Garay (E)

Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, 76230, Juriquilla, Querétaro, C.P, Mexico.

Abraham Cisneros-Mejorado (A)

Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, 76230, Juriquilla, Querétaro, C.P, Mexico.

Manuel B Aguilar (MB)

Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, 76230, Juriquilla, Querétaro, C.P, Mexico.

Fernando Lazcano-Pérez (F)

Unidad Académica de Sistemas Arrecifales Puerto Morelos, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Prolongación Niños Héroes s/n, Domicilio Conocido, C.P. 77580, Puerto Morelos, Quintana Roo, Mexico.

Rogelio O Arellano (RO)

Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Boulevard Juriquilla 3001, 76230, Juriquilla, Querétaro, C.P, Mexico. arellano.ostoa@comunidad.unam.mx.

Judith Sánchez-Rodríguez (J)

Unidad Académica de Sistemas Arrecifales Puerto Morelos, Instituto de Ciencias del Mar y Limnología, Universidad Nacional Autónoma de México, Prolongación Niños Héroes s/n, Domicilio Conocido, C.P. 77580, Puerto Morelos, Quintana Roo, Mexico. judithsa@cmarl.unam.mx.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Sea anemone Bartholomea annulata venom...
Recherchemedicale.com › Facteurs biologiques › Toxines biologiques › Venins › Venins de cnidaires › Sea anemone Bartholomea annulata venom...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Sea anemone Bartholomea annulata venom...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-A › Sea anemone Bartholomea annulata venom...
Recherchemedicale.com › Eucaryotes › Animaux › Invertébrés › Cnidaria › Anthozoa › Anémones de mer › Sea anemone Bartholomea annulata venom...
Recherchemedicale.com › Acides aminés, peptides et protéines › Acides aminés › Amino-butyrates › Acide gamma-amino-butyrique › Sea anemone Bartholomea annulata venom...