Noncoding RNAs in age-related cardiovascular diseases.

Aging / genetics Cardiovascular Diseases / genetics Cardiovascular System / metabolism Heart Humans MicroRNAs / genetics RNA, Long Noncoding / genetics RNA, Untranslated / genetics
Ageing Cardiovascular disease Inflammageing Noncoding RNAs

Journal

Ageing research reviews
ISSN: 1872-9649
Titre abrégé: Ageing Res Rev
Pays: England
ID NLM: 101128963

Informations de publication

Date de publication:
05 2022
Historique:
received: 15 07 2021
revised: 28 01 2022
accepted: 15 03 2022
pubmed: 27 3 2022
medline: 20 4 2022
entrez: 26 3 2022
Statut: ppublish

Résumé

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the adult population worldwide and represent a severe economic burden and public health concern. The majority of human genes do not code for proteins. However, noncoding transcripts play important roles in ageing that significantly increases the risk for CVDs. Noncoding RNAs (ncRNAs) are critical regulators of multiple biological processes related to ageing such as oxidative stress, mitochondrial dysfunction and chronic inflammation. NcRNAs are also involved in pathophysiological developments within the cardiovascular system including arrhythmias, cardiac hypertrophy, fibrosis, myocardial infarction and heart failure. In this review article, we cover the roles of ncRNAs in cardiovascular ageing and disease as well as their potential therapeutic applications in CVDs.

Identifiants

DOI: 10.1016/j.arr.2022.101610 PMID: 35338919
pubmed: 35338919
pii: S1568-1637(22)00052-6
doi: 10.1016/j.arr.2022.101610
pii:
doi:

Substances chimiques

MicroRNAs 0
RNA, Long Noncoding 0
RNA, Untranslated 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

101610

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Amela Jusic (A)

Cardiovascular Research Unit, Luxembourg Institute of Health, Strassen, Luxembourg.

Pınar Buket Thomas (PB)

Department of Medical Biology and Genetics, Maltepe University Faculty of Medicine, Istanbul, Turkey.

Stephanie Bezzina Wettinger (SB)

Department of Applied Biomedical Science, Faculty of Health Sciences, University of Malta, Msida, Malta.

Soner Dogan (S)

Department of Medical Biology, School of Medicine, Yeditepe University, Istanbul, Turkey.

Rosienne Farrugia (R)

Department of Applied Biomedical Science, Faculty of Health Sciences, University of Malta, Msida, Malta.

Carlo Gaetano (C)

Laboratory of Epigenetics, Istituti Clinici Scientifici Maugeri IRCCS, Via Maugeri 10, 27100 Pavia, Italy.

Bilge Güvenç Tuna (BG)

Department of Biophysics, School of Medicine, Yeditepe University, Istanbul, Turkey.

Florence Pinet (F)

INSERM, University of Lille, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, France.

Emma L Robinson (EL)

Consortium for Fibrosis Research & Translation, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; Department of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

Simon Tual-Chalot (S)

Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK.

Konstantinos Stellos (K)

Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, UK; Department of Cardiology, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, UK.

Yvan Devaux (Y)

Cardiovascular Research Unit, Luxembourg Institute of Health, Strassen, Luxembourg. Electronic address: yvan.devaux@lih.lu.

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Classifications MeSH

Recherchemedicale.com › Phénomènes physiologiques › Croissance et développement › Vieillissement › Noncoding RNAs in age-related cardiovascular diseases.
Recherchemedicale.com › Maladies cardiovasculaires › Noncoding RNAs in age-related cardiovascular diseases.
Recherchemedicale.com › Système cardiovasculaire › Noncoding RNAs in age-related cardiovascular diseases.
Recherchemedicale.com › Système cardiovasculaire › Coeur › Noncoding RNAs in age-related cardiovascular diseases.
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Noncoding RNAs in age-related cardiovascular diseases.
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Noncoding RNAs in age-related cardiovascular diseases.
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › ARN long non codant › Noncoding RNAs in age-related cardiovascular diseases.
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Noncoding RNAs in age-related cardiovascular diseases.