Two-component sensor histidine kinases of Mycobacterium tuberculosis: Beacons for niche navigation.
Mycobacterium tuberculosis
TB
antibiotic targets
histidine sensor kinase
two-component transcriptional regulation
Journal
Molecular microbiology
ISSN: 1365-2958
Titre abrégé: Mol Microbiol
Pays: England
ID NLM: 8712028
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
revised:
12
03
2022
received:
22
12
2021
accepted:
22
03
2022
pubmed:
27
3
2022
medline:
31
5
2022
entrez:
26
3
2022
Statut:
ppublish
Résumé
Intracellular bacterial pathogens such as Mycobacterium tuberculosis are remarkably adept at surviving within a host, employing a variety of mechanisms to counteract host defenses and establish a protected niche. Constant surveying of the environment is key for pathogenic mycobacteria to discern their immediate location and coordinate the expression of genes necessary for adaptation. Two-component systems efficiently perform this role, typically comprised of a transmembrane sensor kinase and a cytoplasmic response regulator. In this review, we describe the role of two-component systems in bacterial pathogenesis, focusing predominantly on the role of sensor kinases of M. tuberculosis. We highlight important features of sensor kinases in mycobacterial infection, discuss ways in which these signaling proteins sense and respond to environments, and how this is attuned to their intracellular lifestyle. Finally, we discuss recent studies which have identified and characterized inhibitors of two-component sensor kinases toward establishing a new strategy in anti-mycobacterial therapy.
Identifiants
pubmed: 35338720
doi: 10.1111/mmi.14899
pmc: PMC9321153
doi:
Substances chimiques
Bacterial Proteins
0
Histidine
4QD397987E
Histidine Kinase
EC 2.7.13.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
973-985Informations de copyright
© 2022 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.
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