Role of D-mannose in urinary tract infections - a narrative review.
D-mannose
UTI
Urinary tract infection, Escherichia coli
Journal
Nutrition journal
ISSN: 1475-2891
Titre abrégé: Nutr J
Pays: England
ID NLM: 101152213
Informations de publication
Date de publication:
22 03 2022
22 03 2022
Historique:
received:
11
11
2021
accepted:
04
03
2022
entrez:
22
3
2022
pubmed:
23
3
2022
medline:
8
4
2022
Statut:
epublish
Résumé
Urinary tract infections (UTIs) are one of the most prevalent bacterial diseases worldwide. Despite the efficacy of antibiotics targeted against UTI, the recurrence rates remain significant among the patients. Furthermore, the development of antibiotic resistance is a major concern and creates a demand for alternative treatment options. D-mannose, a monosaccharide naturally found in fruits, is commonly marketed as a dietary supplement for reducing the risk for UTIs. Research suggests that supplemented D-mannose could be a promising alternative or complementary remedy especially as a prophylaxis for recurrent UTIs. When excreted in urine, D-mannose potentially inhibits Escherichia coli, the main causative organism of UTIs, from attaching to urothelium and causing infection. In this review, we provide an overview of UTIs, E. coli pathogenesis and D-mannose and outline the existing clinical evidence of D-mannose in reducing the risk of UTI and its recurrence. Furthermore, we discuss the potential effect mechanisms of D-mannose against uropathogenic E.coli.
Identifiants
pubmed: 35313893
doi: 10.1186/s12937-022-00769-x
pii: 10.1186/s12937-022-00769-x
pmc: PMC8939087
doi:
Substances chimiques
Anti-Bacterial Agents
0
Mannose
PHA4727WTP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
18Informations de copyright
© 2022. The Author(s).
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