Traumatic brain injury and the development of parkinsonism: Understanding pathophysiology, animal models, and therapeutic targets.
CNS Delivery
Concussion
Neurodegeneration
Parkinsonism
Parkinson’s disease
Traumatic Brain Injury
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
18
02
2022
revised:
06
03
2022
accepted:
08
03
2022
pubmed:
16
3
2022
medline:
28
4
2022
entrez:
15
3
2022
Statut:
ppublish
Résumé
The clinical translation of therapeutic approaches to combat debilitating neurodegenerative conditions, such as Parkinson's disease (PD), remains as an urgent unmet challenge. The strong molecular association between the pathogenesis of traumatic brain injury (TBI) and the development of parkinsonism in humans has been well established. Therefore, a lot of ongoing research aims to investigate this pathology overlap in-depth, to exploit the common targets of TBI and PD for development of more effective and long-term treatment strategies. This review article intends to provide a detailed background on TBI pathophysiology and its established overlap with PD with an additional emphasis on the recent findings about their effect on perivascular clearance. Although, the traditional animal models of TBI and PD are still being considered, there is a huge focus on the development of combinatory hybrid animal models coupling concussion with the pre-established PD models for a better recapitulation of the human context of PD pathogenesis. Lastly, the therapeutic targets for TBI and PD, and the contemporary research involving exosomes, DNA vaccines, miRNA, gene therapy and gene editing for the development of potential candidates are discussed, along with the recent development of lesser invasive and promising central nervous system (CNS) drug delivery strategies.
Identifiants
pubmed: 35290887
pii: S0753-3322(22)00200-1
doi: 10.1016/j.biopha.2022.112812
pmc: PMC9050934
mid: NIHMS1790965
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
112812Subventions
Organisme : NINDS NIH HHS
ID : R01 NS108968
Pays : United States
Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.
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