Bile acids and salt-sensitive hypertension: a role of the gut-liver axis.
ENaC
bile acids
gut microbiome
salt-sensitive hypertension
Journal
American journal of physiology. Heart and circulatory physiology
ISSN: 1522-1539
Titre abrégé: Am J Physiol Heart Circ Physiol
Pays: United States
ID NLM: 100901228
Informations de publication
Date de publication:
01 04 2022
01 04 2022
Historique:
pubmed:
5
3
2022
medline:
5
4
2022
entrez:
4
3
2022
Statut:
ppublish
Résumé
Salt-sensitivity of blood pressure (SSBP) affects 50% of the hypertensive and 25% of the normotensive populations. Importantly, SSBP is associated with increased risk for mortality in both populations independent of blood pressure. Despite its deleterious effects, the pathogenesis of SSBP is not fully understood. Emerging evidence suggests a novel role of bile acids in salt-sensitive hypertension and that they may play a crucial role in regulating inflammation and fluid volume homeostasis. Mechanistic evidence implicates alterations in the gut microbiome, the epithelial sodium channel (ENaC), the farnesoid X receptor, and the G protein-coupled bile acid receptor TGR5 in bile acid-mediated effects on cardiovascular function. The mechanistic interplay between excess dietary sodium-induced alterations in the gut microbiome and immune cell activation, bile acid signaling, and whether such interplay may contribute to the etiology of SSBP is still yet to be defined. The main goal of this review is to discuss the potential role of bile acids in the pathogenesis of cardiovascular disease with a focus on salt-sensitive hypertension.
Identifiants
pubmed: 35245132
doi: 10.1152/ajpheart.00027.2022
pmc: PMC8957326
doi:
Substances chimiques
Bile Acids and Salts
0
Sodium Chloride, Dietary
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
H636-H646Subventions
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : K01HL13049
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