A Molecular and Epidemiological Description of a Severe Porcine Reproductive and Respiratory Syndrome Outbreak in a Commercial Swine Production System in Russia.
Animals
Disease Outbreaks
/ veterinary
Epidemiological Monitoring
Evolution, Molecular
Farms
Molecular Epidemiology
Phylogeny
Porcine Reproductive and Respiratory Syndrome
/ epidemiology
Porcine respiratory and reproductive syndrome virus
/ genetics
Russia
/ epidemiology
Swine
Swine Diseases
/ epidemiology
molecular epidemiology
swine production
viral emergence
viral evolution
viral transmission
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
11 02 2022
11 02 2022
Historique:
received:
06
01
2022
revised:
02
02
2022
accepted:
07
02
2022
entrez:
26
2
2022
pubmed:
27
2
2022
medline:
15
3
2022
Statut:
epublish
Résumé
Porcine reproductive and respiratory syndrome (PRRS) is an economically devastating disease of swine in many parts of the world. Porcine reproductive and respiratory syndrome virus (PRRSV) type 1 is endemic in Europe, and prevalence of the subtypes differ spatially. In this study, we investigated a severe PRRS outbreak reported in 30 farms located in eastern Russia that belong to a large swine production company in the region that was also experiencing a pseudorabies outbreak in the system. Data included 28 ORF5 sequences from samples across 18 of the 25 infected sites, reverse transcriptase real-time polymerase chain reaction (RT-qPCR) results from diagnostic testing, reports of clinical signs, and animal movement records. We observed that the outbreak was due to two distinct variants of wildtype PRRSV type 1 subtype 1 with an average genetic distance of 15%. Results suggest that the wildtype PRRSV variants were introduced into the region around 2019, before affecting this production system (i.e., sow farms, nurseries, and finisher farms). Clinical signs did not differ between the variants, but they did differ by stage of pig production. Biosecurity lapses, including movement of animals from infected farms contributed to disease spread.
Identifiants
pubmed: 35215966
pii: v14020375
doi: 10.3390/v14020375
pmc: PMC8875681
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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