Lyotropic Liquid Crystals: A Biocompatible and Safe Material for Local Cardiac Application.
biocompatible material
cardiac tissue regeneration
epicardial application
in vivo studies
lyotropic liquid crystals
rheological characterization
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
20 Feb 2022
20 Feb 2022
Historique:
received:
20
01
2022
revised:
03
02
2022
accepted:
17
02
2022
entrez:
26
2
2022
pubmed:
27
2
2022
medline:
27
2
2022
Statut:
epublish
Résumé
The regeneration of cardiac tissue is a multidisciplinary research field aiming to improve the health condition of the post-heart attack patient. Indeed, myocardial tissue has a poor ability to self-regenerate after severe damage. The scientific efforts focused on the research of a biomaterial able to adapt to heart tissue, thus guaranteeing the in situ release of active substances or growth promoters. Many types of hydrogels were proposed for this purpose, showing several limitations. The aim of this study was to suggest a new usage for glyceryl monooleate-based lyotropic liquid crystals (LLCs) as a biocompatible and inert material for a myocardial application. The main advantages of LLCs are mainly related to their easy in situ injection as lamellar phase and their instant in situ transition in the cubic phase. In vivo studies proved the biocompatibility and the inertia of LLCs after their application on the myocardial tissue of mice. In detail, the cardiac activity was monitored through 28 days, and no significant alterations were recorded in the heart anatomy and functionality. Moreover, gross anatomy showed the ability of LLCs to be bio-degraded in a suitable time frame. Overall, these results permitted us to suppose a potential use of LLCs as materials for cardiac drug delivery.
Identifiants
pubmed: 35214184
pii: pharmaceutics14020452
doi: 10.3390/pharmaceutics14020452
pmc: PMC8879243
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Circulation. 2000 Jun 27;101(25):2981-8
pubmed: 10869273
Eur J Pharm Biopharm. 2004 Sep;58(2):343-56
pubmed: 15296960
Biomaterials. 2019 Oct;217:119289
pubmed: 31254935
Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):221-41
pubmed: 21277921
Int J Pharm. 2015 Jan 30;478(2):569-87
pubmed: 25479099
Molecules. 2020 Apr 23;25(8):
pubmed: 32340329
Sci Rep. 2019 Aug 14;9(1):11810
pubmed: 31413320
J Pharm Sci. 2016 Aug;105(8):2355-64
pubmed: 27339408
Int J Mol Sci. 2020 Oct 18;21(20):
pubmed: 33080988
Langmuir. 2012 Jun 26;28(25):9387-94
pubmed: 22646923
Chem Commun (Camb). 2007 Jan 14;(2):168-70
pubmed: 17180235
Eur Heart J. 2020 Nov 21;41(44):4271-4282
pubmed: 31891403
Cell Death Dis. 2019 Jun 4;10(6):436
pubmed: 31164633
Biomaterials. 2017 Jun;129:37-53
pubmed: 28324864
ACS Appl Mater Interfaces. 2016 May 4;8(17):10752-60
pubmed: 27064934
Expert Opin Drug Deliv. 2013 Jan;10(1):59-72
pubmed: 23140533
J Control Release. 2021 Oct 10;338:623-632
pubmed: 34481927
Circulation. 2012 Jan 3;125(1):e2-e220
pubmed: 22179539
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 Jan-Feb;6(1):15-39
pubmed: 24123919
Bioact Mater. 2021 Jun 20;7:47-72
pubmed: 34466716
Int J Pharm. 2010 Jul 15;394(1-2):92-8
pubmed: 20472044
Int J Mol Sci. 2020 Oct 26;21(21):
pubmed: 33114544
Drug Dev Ind Pharm. 2001 Nov;27(10):1073-81
pubmed: 11794810
Int J Pharm. 2004 Mar 19;272(1-2):151-60
pubmed: 15019078
Acta Biomater. 2019 Nov;99:84-99
pubmed: 31521813
Nanomaterials (Basel). 2017 Oct 14;7(10):
pubmed: 29036920
Biomaterials. 2021 Sep;276:121028
pubmed: 34293701
J Mater Chem B. 2020 Apr 1;8(13):2573-2588
pubmed: 32147675
Drug Deliv Transl Res. 2020 Oct;10(5):1428-1441
pubmed: 32100265
Cell Stem Cell. 2019 Sep 5;25(3):311-327
pubmed: 31491395
Eur J Pharm Biopharm. 2010 Aug;75(3):375-80
pubmed: 20403431
Eur J Pharm Sci. 2012 Jul 16;46(4):189
pubmed: 22521632
J Colloid Interface Sci. 2009 Jan 15;329(2):366-71
pubmed: 18990399
J Pharm Sci. 2018 Mar;107(3):870-878
pubmed: 29108729
Biomater Sci. 2021 Oct 26;9(21):7205-7218
pubmed: 34554160
Phys Chem Chem Phys. 2006 Nov 21;8(43):4957-75
pubmed: 17091149
J Appl Physiol (1985). 2014 Jul 15;117(2):142-52
pubmed: 24876359
EXS. 1996;76:99-114
pubmed: 8805791
ACS Appl Mater Interfaces. 2016 Jun 29;8(25):15948-57
pubmed: 27281488
Carbohydr Polym. 2020 Feb 1;229:115516
pubmed: 31826493
Circulation. 2007 Apr 10;115(14):1895-903
pubmed: 17389262
J Cardiovasc Transl Res. 2011 Oct;4(5):528-42
pubmed: 21710332
Biochim Biophys Acta. 1970;219(1):11-7
pubmed: 5473499
Pediatr Blood Cancer. 2008 Mar;50(3):645-6
pubmed: 16991136
J Neurosci. 2009 Nov 4;29(44):13761-9
pubmed: 19889988
Transplant Direct. 2017 Jul 18;3(8):e198
pubmed: 28795149
Biosens Bioelectron. 2014 Sep 15;59:127-33
pubmed: 24721423
Lancet. 2019 Mar 9;393(10175):1045-1055
pubmed: 30860030
J Control Release. 2014 Jul 10;185:62-70
pubmed: 24794897
Nat Biotechnol. 2018 Aug;36(7):597-605
pubmed: 29969440
Biomaterials. 2013 Sep;34(28):6785-96
pubmed: 23773819
J Mol Biol. 1988 Nov 5;204(1):165-89
pubmed: 3216391
J Pharm Sci. 1997 Jul;86(7):779-85
pubmed: 9232516
Cardiovasc Res. 2021 Apr 19;:
pubmed: 33871588