Lead exposure does not affect baseline and induced innate immunity in quails.
acute-phase protein
birds
innate immune system
metal pollution
white blood cells
Journal
Journal of experimental zoology. Part A, Ecological and integrative physiology
ISSN: 2471-5646
Titre abrégé: J Exp Zool A Ecol Integr Physiol
Pays: United States
ID NLM: 101710204
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
02
02
2022
received:
29
10
2021
accepted:
07
02
2022
pubmed:
22
2
2022
medline:
21
5
2022
entrez:
21
2
2022
Statut:
ppublish
Résumé
Lead (Pb) is one of the most common metals found in ecosystems in elevated concentrations derived mainly from anthropogenic activities. Pb toxicity is of special concern in birds due to its capacity for bioaccumulation in the liver, bones, and kidneys causing physiological disruptions. Such disruptions can be lethal in a few days after Pb acute intoxication and they are associated with several million deaths of birds. Moreover, Pb may work as an immunosuppressant as it affects the cell-mediated and humoral immune responses, including components of the acute-phase response (APR). We (1) examined the effects of Pb contamination on the innate immune system, body mass, and food intake of Japanese quails (Coturnix coturnix japonica), and (2) evaluated the effects of Pb on its APR after exposing the animals to Pb acetate in drinkable water during 7 days. We found that Pb contamination increased the number of circulating white blood cells (WBCs), but no effect was found on body mass, food intake, the heterophil/lymphocyte (H/L) ratio, and haptoglobin (Hp) concentration. When Pb-exposed birds were injected with lipopolysaccharide from Escherichia coli to activate the APR, they had a negative body mass ratio, reduced food intake, and increased the number of WBCs, the H/L ratio, and the Hp concentration. We conclude that Pb exposure at this dose did not affect baseline values of the constitutive response and that it did not affect the APR of quails, but commend for further studies testing the effect of different Pb doses.
Substances chimiques
Lead
2P299V784P
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
527-536Subventions
Organisme : Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México
ID : #814-2018
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
ID : #88888.434131/2019-01
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : #2014/16320-7
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : #2017/17607-6
Informations de copyright
© 2022 Wiley Periodicals LLC.
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