Characterization of the Cellular Microenvironment and Novel Specific Biomarkers in Pterygia Using RNA Sequencing.
FFPE
RNA sequencing
cellular microenvironment
conjunctival pterygium
xCell
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2021
2021
Historique:
received:
25
05
2021
accepted:
24
12
2021
entrez:
17
2
2022
pubmed:
18
2
2022
medline:
18
2
2022
Statut:
epublish
Résumé
With a worldwide prevalence of ~12%, pterygium is a common degenerative and environmentally triggered ocular surface disorder characterized by wing-shaped growth of conjunctival tissue onto the cornea that can lead to blindness if left untreated. This study characterizes the transcriptional profile and the cellular microenvironment of conjunctival pterygia and identifies novel pterygia-specific biomarkers. Formalin-fixed and paraffin-embedded pterygia as well as healthy conjunctival specimens were analyzed using MACE RNA sequencing (
Identifiants
pubmed: 35174178
doi: 10.3389/fmed.2021.714458
pmc: PMC8841401
doi:
Types de publication
Journal Article
Langues
eng
Pagination
714458Informations de copyright
Copyright © 2022 Wolf, Hajdu, Boneva, Schlecht, Lapp, Wacker, Agostini, Reinhard, Auw-Hädrich, Schlunck and Lange.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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