Autoantibody:Autoantigen Competitor Decoys: Application to Cardiac Phenotypes.
autoantibody
autoantigen
autoimmune
decoy
long QT
therapeutics
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
11
2021
accepted:
12
01
2022
entrez:
14
2
2022
pubmed:
15
2
2022
medline:
29
3
2022
Statut:
epublish
Résumé
Autoimmune diseases are often associated with autoantibodies that abnormally target self-antigens (autoantigens). An intuitive therapeutic strategy for diseases caused by aAbs is to design decoys, or soluble molecules that target the antigen combining site of these aAbs, thereby blocking binding of aAb to self-antigen and subsequent tissue damage. Here, we review the known decoy molecules of these types, discuss newer technological opportunities afforded by monoclonal antibody and structural biology advances, and discuss the challenges to this approach. Recent opportunities relevant to this approach for cardiac phenotypes, specifically Ro-associated long QT syndrome, are discussed.
Identifiants
pubmed: 35154130
doi: 10.3389/fimmu.2022.812649
pmc: PMC8832015
doi:
Substances chimiques
Antibodies, Monoclonal
0
Autoantibodies
0
Autoantigens
0
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
812649Informations de copyright
Copyright © 2022 Cardozo, Cardozo and Boutjdir.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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