Suicidal and accidental drug poisoning mortality among older adults and working-age individuals in Spain between 2000 and 2018.
Geriatrics
Intentional drug poisoning
Late-life suicide
Medication error
Journal
BMC geriatrics
ISSN: 1471-2318
Titre abrégé: BMC Geriatr
Pays: England
ID NLM: 100968548
Informations de publication
Date de publication:
10 02 2022
10 02 2022
Historique:
received:
16
04
2021
accepted:
01
02
2022
entrez:
11
2
2022
pubmed:
12
2
2022
medline:
19
3
2022
Statut:
epublish
Résumé
Although medication poisoning in older adults is considered an increasingly important, but preventable cause of death, it has received relatively little attention. We explored recent trends and correlates of suicidal and accidental fatal drug poisonings among older and working-age individuals using nationwide data from Spain. We identified all 15,353 fatal drug poisonings involving decedents aged ≥15 years in Spain between 2000 and 2018 and divided them by age into older adults (≥65 years) and working-age (15-64 years) individuals. For each age group, we analyzed time trends in suicidal and accidental fatal drug poisoning rates (overall and by ICD-10 drug categories) using joinpoint regressions. To understand the specific drugs classified as "Non-psychotropic/non-specified", we used 2018 data including substance-specific ICD-10 supplementary codes. We explored relevant sociodemographic correlates of suicidal and accidental fatal poisoning rates using multivariable negative binomial regressions. Between 2000 and 2018, suicidal fatal poisonings increased faster among older (from 0.19 to 0.63 per 100,000 - average annual change: 7.7%) than working-age individuals (from 0.40 to 0.72 per 100,000 - average annual change: 3.8%). Accidental fatal poisonings increased among older adults (from 0.25 to 2.67 per 100,000 - average annual change: 16.2%) but decreased among working-age counterparts (from 2.38 to 1.42 per 100,000 - average annual change: - 1.9%). Anticoagulants and cardiac-stimulants glycosides accounted for 70% of the 223 accidental fatal poisonings due to non-psychotropic/non-specified drugs registered among older adults in 2018. Roles of gender and urban dwelling in suicidal and accidental poisonings were heterogeneous across age groups. Increases in suicidal drug poisonings were faster among older than working-age individuals. Accidental fatal poisonings increased only among older adults. Our findings that (i) sociodemographic correlates were heterogeneous across age groups and (ii) anticoagulant and cardiac-stimulant glycosides were particularly salient drivers of accidental poisonings among older adults have implications for prevention.
Sections du résumé
BACKGROUND
Although medication poisoning in older adults is considered an increasingly important, but preventable cause of death, it has received relatively little attention. We explored recent trends and correlates of suicidal and accidental fatal drug poisonings among older and working-age individuals using nationwide data from Spain.
METHODS
We identified all 15,353 fatal drug poisonings involving decedents aged ≥15 years in Spain between 2000 and 2018 and divided them by age into older adults (≥65 years) and working-age (15-64 years) individuals. For each age group, we analyzed time trends in suicidal and accidental fatal drug poisoning rates (overall and by ICD-10 drug categories) using joinpoint regressions. To understand the specific drugs classified as "Non-psychotropic/non-specified", we used 2018 data including substance-specific ICD-10 supplementary codes. We explored relevant sociodemographic correlates of suicidal and accidental fatal poisoning rates using multivariable negative binomial regressions.
RESULTS
Between 2000 and 2018, suicidal fatal poisonings increased faster among older (from 0.19 to 0.63 per 100,000 - average annual change: 7.7%) than working-age individuals (from 0.40 to 0.72 per 100,000 - average annual change: 3.8%). Accidental fatal poisonings increased among older adults (from 0.25 to 2.67 per 100,000 - average annual change: 16.2%) but decreased among working-age counterparts (from 2.38 to 1.42 per 100,000 - average annual change: - 1.9%). Anticoagulants and cardiac-stimulants glycosides accounted for 70% of the 223 accidental fatal poisonings due to non-psychotropic/non-specified drugs registered among older adults in 2018. Roles of gender and urban dwelling in suicidal and accidental poisonings were heterogeneous across age groups.
CONCLUSION
Increases in suicidal drug poisonings were faster among older than working-age individuals. Accidental fatal poisonings increased only among older adults. Our findings that (i) sociodemographic correlates were heterogeneous across age groups and (ii) anticoagulant and cardiac-stimulant glycosides were particularly salient drivers of accidental poisonings among older adults have implications for prevention.
Identifiants
pubmed: 35144558
doi: 10.1186/s12877-022-02806-0
pii: 10.1186/s12877-022-02806-0
pmc: PMC8832785
doi:
Substances chimiques
Psychotropic Drugs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
114Informations de copyright
© 2022. The Author(s).
Références
J Clin Epidemiol. 1997 Apr;50(4):367-75
pubmed: 9179094
Crisis. 2020 Mar;41(Suppl 1):S8-S20
pubmed: 32208758
BMC Geriatr. 2021 Mar 20;21(1):197
pubmed: 33743582
Eur J Pain. 2019 Apr;23(4):697-707
pubmed: 30407692
Drug Saf. 2017 Dec;40(12):1241-1248
pubmed: 28698988
Front Pharmacol. 2020 May 14;11:648
pubmed: 32477127
Pharmacoepidemiol Drug Saf. 2020 Apr;29(4):433-443
pubmed: 31908111
Med J Aust. 2017 Mar 6;206(4):164-169
pubmed: 28253466
Int Psychogeriatr. 2021 Feb;33(2):117-119
pubmed: 33750501
J Clin Epidemiol. 2011 Oct;64(10):1102-8
pubmed: 21477992
BMJ Qual Saf. 2021 Feb;30(2):96-105
pubmed: 32527980
Pharmacoepidemiol Drug Saf. 2017 May;26(5):481-497
pubmed: 28295821
Stat Med. 2009 Dec 20;28(29):3670-82
pubmed: 19856324
Lancet. 2020 Oct 17;396(10258):1204-1222
pubmed: 33069326
J Public Health (Oxf). 2013 Jun;35(2):237-45
pubmed: 23292090
Soc Psychiatry Psychiatr Epidemiol. 1999 Nov;34(11):609-14
pubmed: 10651180
BMC Geriatr. 2020 Mar 4;20(1):87
pubmed: 32131742
N Engl J Med. 2018 Apr 26;378(17):1567-1569
pubmed: 29694805
Glob Public Health. 2020 Dec;15(12):1894-1901
pubmed: 32744898
Am J Prev Med. 2014 Sep;47(3 Suppl 2):S244-50
pubmed: 25145746
Drug Saf. 2015 May;38(5):437-53
pubmed: 25822400
Int Psychogeriatr. 2015 Nov;27(11):1757-68
pubmed: 26239355
Rev Psiquiatr Salud Ment (Engl Ed). 2018 Oct - Dec;11(4):227-233
pubmed: 27450705
JAMA Psychiatry. 2020 Jul 1;77(7):684-693
pubmed: 32320023
Stat Med. 2000 Feb 15;19(3):335-51
pubmed: 10649300
JAMA. 2005 Mar 16;293(11):1348-58
pubmed: 15769968
Am J Prev Med. 2019 Apr;56(4):603-613
pubmed: 30777704
BMJ. 2004 Nov 6;329(7474):1076
pubmed: 15516343
Int Psychogeriatr. 2017 Mar;29(3):419-430
pubmed: 27852335
Arch Public Health. 2015 Nov 09;73:50
pubmed: 26557365
Inj Prev. 2012 Oct;18(5):321-5
pubmed: 22157205
Ann Intern Med. 2007 Dec 4;147(11):755-65
pubmed: 18056659
N Engl J Med. 2011 Nov 24;365(21):2002-12
pubmed: 22111719
PLoS One. 2016 Dec 1;11(12):e0167204
pubmed: 27907072
Soc Psychiatry Psychiatr Epidemiol. 2021 May;56(5):721-729
pubmed: 32918553
Br J Psychiatry. 2019 Apr;214(4):186-200
pubmed: 30789112
BMC Geriatr. 2019 Sep 18;19(1):257
pubmed: 31533630
BMC Geriatr. 2011 Dec 07;11:82
pubmed: 22151472
JAMA Psychiatry. 2020 Oct 1;77(10):990-991
pubmed: 32492078
JAMA. 2012 Nov 14;308(18):1865-6
pubmed: 23150006
Farm Hosp. 2018 Sep 01;42(5):197-199
pubmed: 30173637
BMC Geriatr. 2020 Nov 26;20(1):506
pubmed: 33243145
Ann Pharmacother. 2004 Dec;38(12):2005-11
pubmed: 15522976
Int J Geriatr Psychiatry. 2021 Jan;36(1):76-85
pubmed: 32791563