Association between common cardiovascular risk factors and clinical phenotype in patients with hypertrophic cardiomyopathy from the European Society of Cardiology (ESC) EurObservational Research Programme (EORP) Cardiomyopathy/Myocarditis registry.
Cardiovascular risk factors
Diabetes
Genotype
Hypertension
Hypertrophic cardiomyopathy
Obesity
Journal
European heart journal. Quality of care & clinical outcomes
ISSN: 2058-1742
Titre abrégé: Eur Heart J Qual Care Clin Outcomes
Pays: England
ID NLM: 101677796
Informations de publication
Date de publication:
13 12 2022
13 12 2022
Historique:
received:
04
01
2022
revised:
02
02
2022
accepted:
04
02
2022
pubmed:
10
2
2022
medline:
15
12
2022
entrez:
9
2
2022
Statut:
ppublish
Résumé
The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation between CVRF and the clinical characteristics of patients with HCM enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy registry. 1739 patients with HCM were studied. The relation between hypertension (HT), diabetes (DM), body mass index (BMI), and clinical traits was analysed. Analyses were stratified according to the presence or absence of a pathogenic variant in a sarcomere gene. The prevalence of HT, DM, and obesity (Ob) was 37, 10, and 21%, respectively. HT, DM, and Ob were associated with older age (P<0.001), less family history of HCM (HT and DM P<0.001), higher New York Heart Association (NYHA) class (P<0.001), atrial fibrillation (HT and DM P<0.001; Ob p = 0.03) and LV (left ventricular) diastolic dysfunction (HT and Ob P<0.001; DM P = 0.003). Stroke was more frequent in HT (P<0.001) and mutation-positive patients with DM (P = 0.02). HT and Ob were associated with higher provocable LV outflow tract gradients (HT P<0.001, Ob P = 0.036). LV hypertrophy was more severe in Ob (P = 0.018). HT and Ob were independently associated with NYHA class (OR 1.419, P = 0.017 and OR 1.584, P = 0.004, respectively). Other associations, including a higher proportion of females in HT and of systolic dysfunction in HT and Ob, were observed only in mutation-positive patients. Common CVRF are associated with a more severe HCM phenotype, suggesting a proactive management of CVRF should be promoted. An interaction between genotype and CVRF was observed for some traits.
Identifiants
pubmed: 35138368
pii: 6524906
doi: 10.1093/ehjqcco/qcac006
pmc: PMC9745665
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
42-53Subventions
Organisme : Medical Research Council
ID : MR/T024062/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T005181/1
Pays : United Kingdom
Investigateurs
Christopher Peter Gale
(CP)
Branko Beleslin
(B)
Andrzej Budaj
(A)
Ovidiu Chioncel
(O)
Nikolaos Dagres
(N)
Nicolas Danchin
(N)
David Erlinge
(D)
Jonathan Emberson
(J)
Michael Glikson
(M)
Alastair Gray
(A)
Meral Kayikcioglu
(M)
Aldo Maggioni
(A)
Klaudia Vivien Nagy
(KV)
Aleksandr Nedoshivin
(A)
Anna-Sonia Petronio
(AS)
Jolien Roo Hesselink
(JR)
Lars Wallentin
(L)
Uwe Zeymer
(U)
Alida Caforio
(A)
Juan Ramon Gimeno Blanes
(JRG)
Philippe Charron
(P)
Perry Elliott
(P)
Juan Pablo Kaski
(JP)
Aldo P Maggioni
(AP)
Luigi Tavazzi
(L)
Michal Tendera
(M)
S Komissarova
(S)
N Chakova
(N)
S Niyazova
(S)
A Linhart
(A)
P Kuchynka
(P)
T Palecek
(T)
J Podzimkova
(J)
M Fikrle
(M)
E Nemecek
(E)
H Bundgaard
(H)
J Tfelt-Hansen
(J)
J Theilade
(J)
J J Thune
(JJ)
A Axelsson
(A)
J Mogensen
(J)
F Henriksen
(F)
T Hey
(T)
S K Nielsen
(SK)
L Videbaek
(L)
S Andreasen
(S)
H Arnsted
(H)
A Saad
(A)
M Ali
(M)
J Lommi
(J)
T Helio
(T)
M S Nieminen
(MS)
O Dubourg
(O)
N Mansencal
(N)
M Arslan
(M)
V Siam Tsieu
(VS)
T Damy
(T)
A Guellich
(A)
S Guendouz
(S)
C M Tissot
(CM)
A Lamine
(A)
S Rappeneau
(S)
A Hagege
(A)
M Desnos
(M)
A Bachet
(A)
M Hamzaoui
(M)
P Charron
(P)
R Isnard
(R)
L Legrand
(L)
C Maupain
(C)
E Gandjbakhch
(E)
M Kerneis
(M)
J-F Pruny
(JF)
A Bauer
(A)
B Pfeiffer
(B)
S B Felix
(SB)
M Dorr
(M)
S Kaczmarek
(S)
K Lehnert
(K)
A-L Pedersen
(AL)
D Beug
(D)
M Bruder
(M)
M Böhm
(M)
I Kindermann
(I)
Y Linicus
(Y)
C Werner
(C)
B Neurath
(B)
M Schild-Ungerbuehler
(M)
H Seggewiss
(H)
B Pfeiffer
(B)
A Neugebauer
(A)
P McKeown
(P)
A Muir
(A)
J McOsker
(J)
T Jardine
(T)
G Divine
(G)
P Elliott
(P)
M Lorenzini
(M)
O Watkinson
(O)
E Wicks
(E)
H Iqbal
(H)
S Mohiddin
(S)
C O'Mahony
(C)
N Sekri
(N)
G Carr-White
(G)
T Bueser
(T)
R Rajani
(R)
L Clack
(L)
J Damm
(J)
S Jones
(S)
R Sanchez-Vidal
(R)
M Smith
(M)
T Walters
(T)
K Wilson
(K)
S Rosmini
(S)
A Anastasakis
(A)
K Ritsatos
(K)
V Vlagkouli
(V)
T Forster
(T)
R Sepp
(R)
J Borbas
(J)
V Nagy
(V)
A Tringer
(A)
K Kakonyi
(K)
L A Szabo
(LA)
M Maleki
(M)
F Noohi Bezanjani
(FN)
A Amin
(A)
N Naderi
(N)
M Parsaee
(M)
S Taghavi
(S)
B Ghadrdoost
(B)
S Jafari
(S)
M Khoshavi
(M)
C Rapezzi
(C)
E Biagini
(E)
A Corsini
(A)
C Gagliardi
(C)
M Graziosi
(M)
S Longhi
(S)
A Milandri
(A)
L Ragni
(L)
S Palmieri
(S)
I Olivotto
(I)
A Arretini
(A)
G Castelli
(G)
F Cecchi
(F)
A Fornaro
(A)
B Tomberli
(B)
P Spirito
(P)
E Devoto
(E)
P Della Bella
(PD)
G Maccabelli
(G)
S Sala
(S)
F Guarracini
(F)
G Peretto
(G)
M G Russo
(MG)
R Calabro
(R)
G Pacileo
(G)
G Limongelli
(G)
D Masarone
(D)
V Pazzanese
(V)
A Rea
(A)
M Rubino
(M)
S Tramonte
(S)
F Valente
(F)
M Caiazza
(M)
A Cirillo
(A)
G Del Giorno
(G)
A Esposito
(A)
R Gravino
(R)
T Marrazzo
(T)
B Trimarco
(B)
M-A Losi
(MA)
C Di Nardo
(C)
A Giamundo
(A)
F Musella
(F)
F Pacelli
(F)
A Scatteia
(A)
G Canciello
(G)
A Caforio
(A)
S Iliceto
(S)
C Calore
(C)
L Leoni
(L)
M Perazzolo Marra
(MP)
I Rigato
(I)
G Tarantini
(G)
A Schiavo
(A)
M Testolina
(M)
E Arbustini
(E)
A Di Toro
(A)
L P Giuliani
(LP)
A Serio
(A)
F Fedele
(F)
A Frustaci
(A)
M Alfarano
(M)
C Chimenti
(C)
F Drago
(F)
A Baban
(A)
L Calò
(L)
C Lanzillo
(C)
A Martino
(A)
M Uguccioni
(M)
E Zachara
(E)
G Halasz
(G)
F Re
(F)
G Sinagra
(G)
C Carriere
(C)
M Merlo
(M)
F Ramani
(F)
A Kavoliuniene
(A)
A Krivickiene
(A)
E Tamuleviciute-Prasciene
(E)
M Viezelis
(M)
J Celutkiene
(J)
L Balkeviciene
(L)
M Laukyte
(M)
E Paleviciute
(E)
Y Pinto
(Y)
A Wilde
(A)
F W Asselbergs
(FW)
A Sammani
(A)
J Van Der Heijden
(J)
L Van Laake
(L)
N De Jonge
(N)
R Hassink
(R)
J H Kirkels
(JH)
J Ajuluchukwu
(J)
A Olusegun-Joseph
(A)
E Ekure
(E)
K Mizia-Stec
(K)
M Tendera
(M)
A Czekaj
(A)
A Sikora-Puz
(A)
A Skoczynska
(A)
M Wybraniec
(M)
P Rubis
(P)
E Dziewiecka
(E)
S Wisniowska-Smialek
(S)
Z Bilinska
(Z)
P Chmielewski
(P)
B Foss-Nieradko
(B)
E Michalak
(E)
M Stepien-Wojno
(M)
B Mazek
(B)
L Rocha Lopes
(LR)
A R Almeida
(AR)
I Cruz
(I)
A C Gomes
(AC)
A R Pereira
(AR)
D Brito
(D)
H Madeira
(H)
A R Francisco
(AR)
M Menezes
(M)
O Moldovan
(O)
T Oliveira Guimaraes
(TO)
D Silva
(D)
C Ginghina
(C)
R Jurcut
(R)
A Mursa
(A)
B A Popescu
(BA)
E Apetrei
(E)
S Militaru
(S)
I Mircea Coman
(IM)
A Frigy
(A)
Z Fogarasi
(Z)
I Kocsis
(I)
I A Szabo
(IA)
L Fehervari
(L)
I Nikitin
(I)
E Resnik
(E)
M Komissarova
(M)
V Lazarev
(V)
M Shebzukhova
(M)
D Ustyuzhanin
(D)
O Blagova
(O)
I Alieva
(I)
V Kulikova
(V)
Y Lutokhina
(Y)
E Pavlenko
(E)
N Varionchik
(N)
A D Ristic
(AD)
P M Seferovic
(PM)
I Veljic
(I)
I Zivkovic
(I)
I Milinkovic
(I)
A Pavlovic
(A)
G Radovanovic
(G)
D Simeunovic
(D)
M Zdravkovic
(M)
M Aleksic
(M)
J Djokic
(J)
S Hinic
(S)
S Klasnja
(S)
K Mircetic
(K)
L Monserrat
(L)
X Fernandez
(X)
D Garcia-Giustiniani
(D)
J M Larrañaga
(JM)
M Ortiz-Genga
(M)
R Barriales-Villa
(R)
C Martinez-Veira
(C)
E Veira
(E)
A Cequier
(A)
J Salazar-Mendiguchia
(J)
N Manito
(N)
J Gonzalez
(J)
F Fernández-Avilés
(F)
C Medrano
(C)
R Yotti
(R)
S Cuenca
(S)
M A Espinosa
(MA)
I Mendez
(I)
E Zatarain
(E)
R Alvarez
(R)
P Garcia Pavia
(PG)
A Briceno
(A)
M Cobo-Marcos
(M)
F Dominguez
(F)
E De Teresa Galvan
(ET)
J M García Pinilla
(JMG)
N Abdeselam-Mohamed
(N)
M A Lopez-Garrido
(MA)
L Morcillo Hidalgo
(LM)
M V Ortega-Jimenez
(MV)
A Robles Mezcua
(AR)
A Guijarro-Contreras
(A)
D Gomez-Garcia
(D)
M Robles-Mezcua
(M)
J R Gimeno Blanes
(JRG)
F J Castro
(FJ)
C Munoz Esparza
(CM)
M Sabater Molina
(MS)
M Sorli García
(MS)
D Lopez Cuenca
(DL)
Palma de Mallorca
(P)
T Ripoll-Vera
(T)
J Alvarez
(J)
J Nunez
(J)
Y Gomez
(Y)
P L Sanchez Fernandez
(PLS)
E Villacorta
(E)
C Avila
(C)
L Bravo
(L)
E Diaz-Pelaez
(E)
M Gallego-Delgado
(M)
L Garcia-Cuenllas
(L)
B Plata
(B)
J E Lopez-Haldon
(JE)
M L Pena Pena
(ML)
E M Cantero Perez
(EMC)
E Zorio
(E)
M A Arnau
(MA)
J Sanz
(J)
E Marques-Sule
(E)
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.
Références
Curr Diab Rep. 2019 Jun 20;19(7):44
pubmed: 31222515
Eur Heart J. 2016 Aug 1;37(29):2315-2381
pubmed: 27222591
Eur Heart J. 2020 Jan 7;41(2):255-323
pubmed: 31497854
Eur J Heart Fail. 2015 Aug;17(8):837-45
pubmed: 26183688
Eur Heart J Qual Care Clin Outcomes. 2018 Jan 1;4(1):1-3
pubmed: 29177406
JAMA Cardiol. 2020 Jan 1;5(1):65-72
pubmed: 31693057
Am J Med Sci. 2016 Aug;352(2):219-22
pubmed: 27524223
Eur Heart J. 2018 May 21;39(20):1784-1793
pubmed: 29378019
Eur Heart J. 2016 Jan 7;37(2):164-73
pubmed: 26409010
Heart Fail Clin. 2019 Jul;15(3):341-347
pubmed: 31079692
J Am Coll Cardiol. 2013 Jul 30;62(5):449-57
pubmed: 23643593
Eur Heart J. 2019 Jun 1;40(21):1671-1677
pubmed: 30358878
Hypertension. 2018 Sep;72(3):549-558
pubmed: 30354762
Eur Heart J. 2018 Sep 1;39(33):3021-3104
pubmed: 30165516
Circ Heart Fail. 2012 Jul 1;5(4):535-46
pubmed: 22811549
Circ Heart Fail. 2018 Sep;11(9):e005191
pubmed: 30354366
Eur Heart J. 2014 Oct 14;35(39):2733-79
pubmed: 25173338
Eur Heart J. 2016 Jun 14;37(23):1815-22
pubmed: 26497160
Rev Esp Cardiol (Engl Ed). 2018 Mar;71(3):146-154
pubmed: 28687478