Architectural control of mesenchymal stem cell phenotype through nuclear actin.
Arp2/3
Mechanoresponse
cofilin
epigenetics
formin
mechanical-strain
mesenchymal stem cell
Journal
Nucleus (Austin, Tex.)
ISSN: 1949-1042
Titre abrégé: Nucleus
Pays: United States
ID NLM: 101518322
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
entrez:
8
2
2022
pubmed:
9
2
2022
medline:
1
4
2022
Statut:
ppublish
Résumé
There is growing appreciation that architectural components of the nucleus regulate gene accessibility by altering chromatin organization. While nuclear membrane connector proteins link the mechanosensitive actin cytoskeleton to the nucleoskeleton, actin's contribution to the inner architecture of the nucleus remains enigmatic. Control of actin transport into the nucleus, plus the presence of proteins that control actin structure (the actin tool-box) within the nucleus, suggests that nuclear actin may support biomechanical regulation of gene expression. Cellular actin structure is mechanoresponsive: actin cables generated through forces experienced at the plasma membrane transmit force into the nucleus. We posit that dynamic actin remodeling in response to such biomechanical cues provides a novel level of structural control over the epigenetic landscape. We here propose to bring awareness to the fact that mechanical forces can promote actin transfer into the nucleus and control structural arrangements as illustrated in mesenchymal stem cells, thereby modulating lineage commitment.
Identifiants
pubmed: 35133922
doi: 10.1080/19491034.2022.2029297
pmc: PMC8837231
doi:
Substances chimiques
Actins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
35-48Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM103408
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM109095
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR075803
Pays : United States
Organisme : NIH HHS
ID : S10 OD032354
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059923
Pays : United States
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