Elevated proportion of TLR2- and TLR4-expressing Th17-like cells and activated memory B cells was associated with clinical activity of cerebral cavernous malformations.
B cells
Cerebral cavernous malformations
Cytokines
LPS
T cells
TLR
Th17 cells
Journal
Journal of neuroinflammation
ISSN: 1742-2094
Titre abrégé: J Neuroinflammation
Pays: England
ID NLM: 101222974
Informations de publication
Date de publication:
02 Feb 2022
02 Feb 2022
Historique:
received:
31
07
2021
accepted:
12
01
2022
entrez:
3
2
2022
pubmed:
4
2
2022
medline:
8
4
2022
Statut:
epublish
Résumé
Recent evidences have suggested the involvement of toll-like receptor (TLR)-4 in the pathogenesis of cerebral cavernous malformations (CCM). Elevated frequency of TLR For our study, the cytokine profile from TLR2 CCM Our findings reveal an increase in circulating Th17/Tc-17 cell subsets expressing functional TLR2 and, mainly, TLR4 molecules, associated with an increase in memory B-cell subsets in CCM patients with clinical activity of the disease.
Sections du résumé
BACKGROUND
BACKGROUND
Recent evidences have suggested the involvement of toll-like receptor (TLR)-4 in the pathogenesis of cerebral cavernous malformations (CCM). Elevated frequency of TLR
METHODS
METHODS
For our study, the cytokine profile from TLR2
RESULTS
RESULTS
CCM
CONCLUSIONS
CONCLUSIONS
Our findings reveal an increase in circulating Th17/Tc-17 cell subsets expressing functional TLR2 and, mainly, TLR4 molecules, associated with an increase in memory B-cell subsets in CCM patients with clinical activity of the disease.
Identifiants
pubmed: 35109870
doi: 10.1186/s12974-022-02385-2
pii: 10.1186/s12974-022-02385-2
pmc: PMC8808981
doi:
Substances chimiques
TLR2 protein, human
0
TLR4 protein, human
0
Toll-Like Receptor 2
0
Toll-Like Receptor 4
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
28Informations de copyright
© 2022. The Author(s).
Références
Trends Immunol. 2014 Sep;35(9):436-42
pubmed: 24998903
J Immunol. 2014 Jul 15;193(2):627-34
pubmed: 24928999
Sci Transl Med. 2019 Nov 27;11(520):
pubmed: 31776290
Immunology. 2018 Jun;154(2):239-252
pubmed: 29168181
J Exp Med. 2010 Apr 12;207(4):881-96
pubmed: 20308363
J Immunol. 2004 Feb 1;172(3):1380-90
pubmed: 14734713
Clin Dev Immunol. 2012;2012:836485
pubmed: 22737174
Ann N Y Acad Sci. 2014 May;1317:70-5
pubmed: 24673331
J Neuroinflammation. 2017 Jun 9;14(1):117
pubmed: 28599652
Annu Rev Pathol. 2020 Jan 24;15:493-518
pubmed: 31675482
Neurosurgery. 1995 Oct;37(4):591-605
pubmed: 8559286
Front Cell Neurosci. 2014 Jul 04;8:187
pubmed: 25071447
Front Immunol. 2019 Sep 24;10:2221
pubmed: 31608054
J Immunol. 2015 Jun 1;194(11):5085-93
pubmed: 25917097
Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H926-H927
pubmed: 18689494
Nature. 2017 May 18;545(7654):305-310
pubmed: 28489816
Immunology. 2016 Feb;147(2):212-20
pubmed: 26781085
Am J Clin Exp Immunol. 2013 Feb 27;2(1):75-93
pubmed: 23885326
Front Immunol. 2019 May 17;10:1081
pubmed: 31156634
Stroke. 2009 May;40(5):1659-65
pubmed: 19286587
Annu Rev Immunol. 2016 May 20;34:335-68
pubmed: 26907215
Arthritis Res. 2002;4 Suppl 3:S197-211
pubmed: 12110140
Stroke. 2018 Apr;49(4):1029-1035
pubmed: 29535273
Immunology. 2021 Mar;162(3):290-305
pubmed: 33112414
Int Rev Immunol. 2015;34(4):318-31
pubmed: 25259411
J Neuroimmunol. 2014 Jul 15;272(1-2):67-75
pubmed: 24864012
Stroke. 2019 May;50(5):1294-1301
pubmed: 30909834
Cell Mol Life Sci. 2021 Feb;78(4):1233-1261
pubmed: 33057840
JCI Insight. 2019 Jun 20;4(12):
pubmed: 31217347
Nat Immunol. 2004 Jan;5(1):98-103
pubmed: 14661019
Mult Scler Relat Disord. 2019 Sep;34:66-76
pubmed: 31229737
Immune Netw. 2018 Aug 13;18(4):e27
pubmed: 30181915
Clin Rheumatol. 2020 May;39(5):1415-1421
pubmed: 32088800
Neurol Ther. 2019 Jun;8(1):45-57
pubmed: 30506485
J Neurosurg. 2019 Jul 1;131(1):1-13
pubmed: 31261134
Circ Res. 2018 Jun 8;122(12):1716-1721
pubmed: 29720384
J Neuroimmune Pharmacol. 2016 Jun;11(2):369-77
pubmed: 27086141
Nat Immunol. 2018 Jul;19(7):665-673
pubmed: 29925983
Cytometry A. 2014 Jan;85(1):36-42
pubmed: 24009159
Adv Immunol. 2010;105:99-130
pubmed: 20510731
Mediators Inflamm. 2018 Aug 19;2018:7328057
pubmed: 30210263
Transl Stroke Res. 2018 Feb;9(1):34-43
pubmed: 28819935
Cell Biochem Biophys. 2014 Sep;70(1):37-49
pubmed: 24639111
J Histochem Cytochem. 2018 Apr;66(4):213-227
pubmed: 29290139
J Neuroimmunol. 2017 Jun 15;307:82-90
pubmed: 28495144
Nat Immunol. 2001 Jul;2(7):620-4
pubmed: 11429546
PLoS One. 2016 Sep 22;11(9):e0162209
pubmed: 27657694
Brain Behav Immun. 2017 Aug;64:71-79
pubmed: 28336414
J Autoimmun. 2020 Jul;111:102461
pubmed: 32305296
Immunity. 2019 May 21;50(5):1132-1148
pubmed: 31117010
Shock. 2006 Aug;26(2):174-9
pubmed: 16878026
Brain. 2018 May 1;141(5):1334-1349
pubmed: 29659729
Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8391-6
pubmed: 26106158
Clin Immunol. 2013 Aug;148(2):209-18
pubmed: 23778260
Cell. 2011 Nov 11;147(4):868-80
pubmed: 22078883
Circ Res. 2021 Jun 25;129(1):195-215
pubmed: 34166073