The emergence of COVID-19 associated mucormycosis: a review of cases from 18 countries.

COVID-19 / complications Diabetes Mellitus / epidemiology Humans Mucormycosis / complications RNA, Viral Risk Factors SARS-CoV-2

Journal

The Lancet. Microbe
ISSN: 2666-5247
Titre abrégé: Lancet Microbe
Pays: England
ID NLM: 101769019

Informations de publication

Date de publication:
07 2022
Historique:
pubmed: 1 2 2022
medline: 2 7 2022
entrez: 31 1 2022
Statut: ppublish

Résumé

Reports of COVID-19-associated mucormycosis have been increasing in frequency since early 2021, particularly among patients with uncontrolled diabetes. Patients with diabetes and hyperglycaemia often have an inflammatory state that could be potentiated by the activation of antiviral immunity to SARS-CoV2, which might favour secondary infections. In this Review, we analysed 80 published and unpublished cases of COVID-19-associated mucormycosis. Uncontrolled diabetes, as well as systemic corticosteroid treatment, were present in most patients with COVID-19-associated mucormycosis, and rhino-orbital cerebral mucormycosis was the most frequent disease. Mortality was high at 49%, which was particularly due to patients with pulmonary or disseminated mucormycosis or cerebral involvement. Furthermore, a substantial proportion of patients who survived had life-changing morbidities (eg, loss of vision in 46% of survivors). Our Review indicates that COVID-19-associated mucormycosis is associated with high morbidity and mortality. Diagnosis of pulmonary mucormycosis is particularly challenging, and might be frequently missed in India.

Identifiants

DOI: 10.1016/S2666-5247(21)00237-8 PMID: 35098179 PMC: PMC8789240
pubmed: 35098179
doi: 10.1016/S2666-5247(21)00237-8
pii: S2666-5247(21)00237-8
pmc: PMC8789240
doi:

Substances chimiques

RNA, Viral 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

e543-e552

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR001442
Pays : United States

Informations de copyright

© 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.

Déclaration de conflit d'intérêts

MH received research funding from Gilead, Pfizer, Astellas, Scynexis, and US National Institutes of Health. J-PG received speaker and expert advice fees from Pfizer and Gilead. NK has received research grants or honoraria as a speaker or advisor from Astellas, Gilead, MSD, and Pfizer, outside the submitted work. KL received consultancy fees from SMB Laboratories Brussels, MSD, and Gilead; travel support from Pfizer; speaker fees from FUJIFILM Wako, Pfizer, and Gilead; and a service fee from Thermo Fisher Scientific. OAC reports grants or contracts from Amplyx, Basilea, BMBF, Cidara, DZIF, EU-DG RTD (101037867), F2G, Gilead, Matinas, MedPace, MSD, Mundipharma, Octapharma, Pfizer, and Scynexis; Consulting fees from Amplyx, Biocon, Biosys, Cidara, Da Volterra, Gilead, Matinas, MedPace, Menarini, Molecular Partners, MSG-ERC, Noxxon, Octapharma, PSI, Scynexis, and Seres; honoraria for lectures from Abbott, Al-Jazeera Pharmaceuticals, Astellas, Grupo Biotoscana/United Medical/Knight, Hikma, MedScape, MedUpdate, Merck/MSD, Mylan, and Pfizer; payment for expert testimony from Cidara; participation on a data safety monitoring board or advisory board from Actelion, Allecra, Cidara, Entasis, IQVIA, Jannsen, MedPace, Paratek, PSI, and Shionogi; a patent at the German Patent and Trade Mark Office (DE 10 2021 113 0077); and other interests from DGHO, DGI, ECMM, ISHAM, MSG-ERC, and Wiley. JRP received research support from Amplyx, Appili, and Astellas; and honoraria and consulting fees from Pfizer, Appili, and Matinas. PLW has done diagnostic evaluations and received meeting sponsorship from Bruker, Dynamiker, and Launch Diagnostics; speakers fees, expert advice fees, and meeting sponsorship from Gilead; speaker and expert advice fees from F2G; speaker fees MSD and Pfizer; and is a founding member of the European Aspergillus PCR Initiative. ACh received funding support from an educational grant from Pfizer, MSD, and Gilead.

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Auteurs

Martin Hoenigl (M)

Division of Infectious Diseases, ECMM Center of Excellence for Medical Mycology, Medical University of Graz, Graz, Austria.
Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California San Diego, La Jolla, CA, USA.
Clinical and Translational Fungal Working Group, University of California San Diego, La Jolla, CA, USA.

Danila Seidel (D)

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.
Department of Internal Medicine, ECMM Center of Excellence for Medical Mycology, University of Cologne, Cologne, Germany.
German Centre for Infection Research, Partner Site Bonn-Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.

Agostinho Carvalho (A)

Life and Health Sciences Research Institute, School of Medicine, University of Minho, Braga, Portugal.
PT Government Associate Laboratory, Guimarães, Portugal.

Shivaprakash M Rudramurthy (SM)

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Amir Arastehfar (A)

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, NJ, USA.

Jean-Pierre Gangneux (JP)

Environnement et Travail, Univ Rennes, CHU Rennes, Inserm, Institut de Recherche en Santé, Rennes, France.

Nosheen Nasir (N)

Section of Adult Infectious Diseases, Department of Medicine, Aga Khan University Karachi, Karachi, Pakistan.

Alexandro Bonifaz (A)

Dermatology Service, Hospital General De México Dr Eduardo Liceaga, Mexico City, Mexico.

Javier Araiza (J)

Dermatology Service, Hospital General De México Dr Eduardo Liceaga, Mexico City, Mexico.

Nikolai Klimko (N)

Department of Clinical Mycology, Allergy and Immunology, North Western State Medical University named after II Mechnikov, St Petersburg, Russia.

Alexandra Serris (A)

Department of Infectious Diseases, Necker-Enfants Malades University Hospital, Paris, France.

Katrien Lagrou (K)

Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium.
Department of Laboratory Medicine and National Reference Centre for Mycosis, ECMM Center of Excellence for Medical Mycology, University Hospitals Leuven, Leuven, Belgium.

Jacques F Meis (JF)

Department of Medical Microbiology and Infectious Diseases, ECMM Center of Excellence for Medical Mycology, Radboud University Medical Center, Canisius Wilhelmina Hospital, Nijmegen, Netherlands.
Center of Expertise in Mycology, Radboud University Medical Center, Canisius Wilhelmina Hospital, Nijmegen, Netherlands.
Bioprocess Engineering and Biotechnology Graduate Program, Federal University of Paraná, Curitiba, Brazil.

Oliver A Cornely (OA)

Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany.
Department of Internal Medicine, ECMM Center of Excellence for Medical Mycology, University of Cologne, Cologne, Germany.
German Centre for Infection Research, Partner Site Bonn-Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Clinical Trials Centre Cologne, ZKS Köln, University of Cologne, Cologne, Germany.

John R Perfect (JR)

Division of Infectious Diseases, Duke University Medical Center, Durham, NC, USA.

P Lewis White (PL)

Public Health Wales Mycology Reference Laboratory, UHW, Cardiff, UK.

Arunaloke Chakrabarti (A)

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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Classifications MeSH

Recherchemedicale.com › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › The emergence of COVID-19 associated...
Recherchemedicale.com › Maladies endocriniennes › Diabète › The emergence of COVID-19 associated...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The emergence of COVID-19 associated...
Recherchemedicale.com › Infection › Infections bactériennes et mycoses › Mycoses › Zygomycose › Mucormycose › The emergence of COVID-19 associated...
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN viral › The emergence of COVID-19 associated...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › The emergence of COVID-19 associated...
Recherchemedicale.com › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › The emergence of COVID-19 associated...