Simulating the Hydrodynamic Conditions of the Human Ascending Colon: A Digital Twin of the Dynamic Colon Model.
Dynamic Colon Model (DCM)
Magnetic Resonance Imaging (MRI)
Smoothed Particle Hydrodynamics (SPH)
colon
colon targeted drug delivery
digital twin
discrete multiphysics
dissolution apparatus
large intestine
shear rate
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
13 Jan 2022
13 Jan 2022
Historique:
received:
09
12
2021
revised:
26
12
2021
accepted:
11
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
22
1
2022
Statut:
epublish
Résumé
The performance of solid oral dosage forms targeting the colon is typically evaluated using standardised pharmacopeial dissolution apparatuses. However, these fail to replicate colonic hydrodynamics. This study develops a digital twin of the Dynamic Colon Model; a physiologically representative in vitro model of the human proximal colon. Magnetic resonance imaging of the Dynamic Colon Model verified that the digital twin robustly replicated flow patterns under different physiological conditions (media viscosity, volume, and peristaltic wave speed). During local contractile activity, antegrade flows of 0.06-0.78 cm s
Identifiants
pubmed: 35057077
pii: pharmaceutics14010184
doi: 10.3390/pharmaceutics14010184
pmc: PMC8778200
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Medical Research Council
ID : MC_PC_18040
Pays : United Kingdom
Organisme : EPSRC Centre for Doctoral Training in Formulation Engineering
ID : EP/L015153/1
Organisme : Engineering and Physical Sciences Research Council
ID : EP/S019227/1
Commentaires et corrections
Type : ErratumIn
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