Enhancing
Saccharomyces cerevisiae
Taxol
bioprocess optimization
high-throughput microbioreactor
nutritional stress
pseudohyphae
scale-up
taxadien-5α-yl acetate
taxadiene-5α-ol
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
13 Jan 2022
13 Jan 2022
Historique:
received:
29
11
2021
revised:
10
01
2022
accepted:
10
01
2022
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
22
1
2022
Statut:
epublish
Résumé
The recent technological advancements in synthetic biology have demonstrated the extensive potential socio-economic benefits at laboratory scale. However, translations of such technologies to industrial scale fermentations remains a major bottleneck. The existence and lack of understanding of the major discrepancies in cultivation conditions between scales often leads to the selection of suboptimal bioprocessing conditions, crippling industrial scale productivity. In this study, strategic design of experiments approaches were coupled with state-of-the-art bioreactor tools to characterize and overcome nutritional stress for the enhanced production of precursors to the blockbuster chemotherapy drug, Taxol, in
Identifiants
pubmed: 35056611
pii: microorganisms10010163
doi: 10.3390/microorganisms10010163
pmc: PMC8778766
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Engineering and Physical Sciences Research Council
ID : EP/R513209/1
Organisme : Royal Society
ID : RSG\R1\180345
Organisme : British Council
ID : 527429894
Organisme : Novo Nordisk (Denmark)
ID : NNF17SA0031362
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