Curcumin Nanoparticles Enhance Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation.
carrageenan
curcumin
diclofenac sodium
nanoparticles
paw edema
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
28 Dec 2021
28 Dec 2021
Historique:
received:
29
11
2021
revised:
20
12
2021
accepted:
24
12
2021
entrez:
21
1
2022
pubmed:
22
1
2022
medline:
22
1
2022
Statut:
epublish
Résumé
We investigated the in vivo effect of curcumin nanoparticles (nC) in addition to diclofenac sodium on local edema and oxidative stress parameters in carrageenan-induced paw edema on rats. Seven groups were investigated: control group (C), the acute inflammation (AI) group, an AI group treated with Diclofenac (AID, 5 mg/kg b.w. Diclofenac sodium), two AI groups treated with cC (conventional Curcumin)-AIC200 and AIcC200D (D = Diclofenac, 200 represent the concentration of active substance expressed in mg/kg b.w.), and two AI groups with nC (Curcumin nanoparticles)-AIC200 and AIcC200D. Serum and tissue oxidative stress was assessed by measuring five parameters. Curcumin nanoparticles alone and in combination with D better reduced the paw edema than D alone (
Identifiants
pubmed: 35052741
pii: biomedicines10010061
doi: 10.3390/biomedicines10010061
pmc: PMC8773028
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Iuliu Hațieganu University of Medicine and Pharmacy
ID : PCD 1032/16/13th of January 2021.
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