Postprandial Glucose Excursions in Asian Versus Non-Asian Patients with Type 2 Diabetes: A Post Hoc Analysis of Baseline Data from Phase 3 Randomised Controlled Trials of IDegAsp.
Asian
Diabetes management
IDegAsp
Postprandial glucose excursion
Type 2 diabetes
Journal
Diabetes therapy : research, treatment and education of diabetes and related disorders
ISSN: 1869-6953
Titre abrégé: Diabetes Ther
Pays: United States
ID NLM: 101539025
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
10
09
2021
accepted:
22
12
2021
pubmed:
20
1
2022
medline:
20
1
2022
entrez:
19
1
2022
Statut:
ppublish
Résumé
Increased postprandial glucose (PPG) is associated with high glycated haemoglobin levels and is an independent risk factor for cardiovascular diseases. The aim of this study was to compare PPG increments in Asian versus non-Asian adults with type 2 diabetes (T2D), who were insulin-naïve or insulin-experienced, from the phase 3 insulin degludec/insulin aspart (IDegAsp) clinical trials. This was a post hoc analysis of data from 13 phase 3, randomised, parallel-group, open-label IDegAsp trials in patients with T2D. The pooled baseline clinical data were analysed for insulin-naïve and insulin-experienced groups; and each group was split into subgroups of Asian and non-Asian patients, respectively, and analysed accordingly. Baseline self-monitored blood glucose (SMBG) values at breakfast, lunch and the evening meal (before and 90 min after each meal) were used to assess PPG increments. The estimated differences in baseline SMBG increment between the Asian and non-Asian subgroups were analysed. Clinical data from 4750 participants (insulin-naïve, n = 1495; insulin-experienced, n = 3255) were evaluated. In the insulin-naïve group, the postprandial SMBG increment was significantly greater in the Asian versus the non-Asian subgroup at breakfast (estimated difference 28.67 mg/dL, 95% confidence interval [CI] 18.35, 38.99; p < 0.0001), lunch (17.34 mg/dL, 95% CI 6.47, 28.21; p = 0.0018) and the evening meal (16.19 mg/dL, 95% CI 5.04, 27.34; p = 0.0045). In the insulin-experienced group, the postprandial SMBG increment was significantly greater in the Asian versus non-Asian subgroup at breakfast (estimated difference 13.81 mg/dL, 95% CI 9.19, 18.44; p < 0.0001) and lunch (29.18 mg/dL, 95% CI 24.22, 34.14; p < 0.0001), but not significantly different at the evening meal. In this post hoc analysis, baseline PPG increments were significantly greater in Asian participants with T2D than in their non-Asian counterparts at all mealtimes, with the exception of the evening meal in insulin-experienced participants. Asian adults with T2D may benefit from the use of regimens that control PPG excursions. NCT02762578, NCT01814137, NCT01513590, NCT01009580, NCT01713530, NCT02648217, NCT01045447, NCT01365507, NCT01045707, NCT01272193, NCT01059812, NCT01680341, NCT02906917.
Identifiants
pubmed: 35044568
doi: 10.1007/s13300-021-01196-7
pii: 10.1007/s13300-021-01196-7
pmc: PMC8873325
doi:
Banques de données
ClinicalTrials.gov
['NCT02762578', 'NCT01814137', 'NCT01513590', 'NCT01009580', 'NCT01713530', 'NCT02648217', 'NCT01045447', 'NCT01365507', 'NCT01045707', 'NCT01272193', 'NCT01059812', 'NCT01680341', 'NCT02906917', 'NCT01513590', 'NCT01045707', 'NCT01045447', 'NCT01059812', 'NCT01272193', 'NCT01009580', 'NCT01365507', 'NCT02648217', 'NCT01814137', 'NCT02906917', 'NCT29069172', 'NCT01713530', 'NCT02762578', 'NCT01680341']
Types de publication
Journal Article
Langues
eng
Pagination
311-323Informations de copyright
© 2022. The Author(s).
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