Differential Afa/Dr Fimbriae Expression in the Multidrug-Resistant Escherichia coli ST131 Clone.
adhesins
antibiotic resistance
fimbriae
uropathogenic Escherichia coli
virulence regulation
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
22 02 2022
22 02 2022
Historique:
entrez:
18
1
2022
pubmed:
19
1
2022
medline:
3
3
2023
Statut:
ppublish
Résumé
Many antibiotic resistant uropathogenic Escherichia coli (UPEC) strains belong to clones defined by their multilocus sequence type (ST), with ST131 being the most dominant. Although we have a good understanding of resistance development to fluoroquinolones and third-generation cephalosporins by ST131, our understanding of the virulence repertoire that has contributed to its global dissemination is limited. Here we show that the genes encoding Afa/Dr fimbriae, a group of adhesins strongly associated with UPEC that cause gestational pyelonephritis and recurrent cystitis, are found in approximately one third of all ST131 strains. Sequence comparison of the AfaE adhesin protein revealed a unique allelic variant carried by 82.9% of
Identifiants
pubmed: 35038925
doi: 10.1128/mbio.03519-21
pmc: PMC8764528
doi:
Substances chimiques
Adhesins, Bacterial
0
Anti-Bacterial Agents
0
DNA Transposable Elements
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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