Paternally expressed gene 3 (Pw1/Peg3) promotes sexual dimorphism in metabolism and behavior.
Adiposity
Animals
Body Size
Female
Gene Expression Regulation, Developmental
Gene Knockout Techniques
Genomic Imprinting
Insulin-Like Growth Factor I
/ metabolism
Intercellular Signaling Peptides and Proteins
/ metabolism
Kruppel-Like Transcription Factors
/ genetics
Male
Mice
Paternal Inheritance
Phenotype
Sex Characteristics
Journal
PLoS genetics
ISSN: 1553-7404
Titre abrégé: PLoS Genet
Pays: United States
ID NLM: 101239074
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
26
04
2021
accepted:
20
12
2021
revised:
26
01
2022
pubmed:
14
1
2022
medline:
19
2
2022
entrez:
13
1
2022
Statut:
epublish
Résumé
The paternally expressed gene 3 (Pw1/Peg3) is a mammalian-specific parentally imprinted gene expressed in stem/progenitor cells of the brain and endocrine tissues. Here, we compared phenotypic characteristics in Pw1/Peg3 deficient male and female mice. Our findings indicate that Pw1/Peg3 is a key player for the determination of sexual dimorphism in metabolism and behavior. Mice carrying a paternally inherited Pw1/Peg3 mutant allele manifested postnatal deficits in GH/IGF dependent growth before weaning, sex steroid dependent masculinization during puberty, and insulin dependent fat accumulation in adulthood. As a result, Pw1/Peg3 deficient mice develop a sex-dependent global shift of body metabolism towards accelerated adiposity, diabetic-like insulin resistance, and fatty liver. Furthermore, Pw1/Peg3 deficient males displayed reduced social dominance and competitiveness concomitant with alterations in the vasopressinergic architecture in the brain. This study demonstrates that Pw1/Peg3 provides an epigenetic context that promotes male-specific characteristics through sex steroid pathways during postnatal development.
Identifiants
pubmed: 35025875
doi: 10.1371/journal.pgen.1010003
pii: PGENETICS-D-21-00562
pmc: PMC8791484
doi:
Substances chimiques
Intercellular Signaling Peptides and Proteins
0
Kruppel-Like Transcription Factors
0
Peg3 protein, mouse
0
insulin-like growth factor-1, mouse
0
Insulin-Like Growth Factor I
67763-96-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1010003Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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