Spindle Variant Primary Diffuse Large B Cell Lymphoma of the Colon: Case Report and Literature Review.
Colon
Diffuse large B cell lymphoma
Spindle cell
Journal
Journal of gastrointestinal cancer
ISSN: 1941-6636
Titre abrégé: J Gastrointest Cancer
Pays: United States
ID NLM: 101479627
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
accepted:
17
12
2021
medline:
15
5
2023
pubmed:
12
1
2022
entrez:
11
1
2022
Statut:
ppublish
Résumé
Diffuse large B cell lymphoma (DLBCL) with spindle cell morphology is a rare variant that can be seen in extranodal regions. Because the spindle cell dominant morphology in lymphoma is extremely unusual, the diagnosis can easily be missed in many organ systems. We present a case of an 82-year-old male patient with complaints of abdominal pain and swelling. He operated with the preliminary diagnosis of cecum tumor and ileum perforation. Tumoral proliferation was observed originating from the submucosa and infiltrating the muscularis propria, with the features of mostly spindle-shaped, having round-shaped nuclei in some of the cells, and having relatively narrow cytoplasm. A panel of immunohistochemical stains were performed to rule out the possibilities of sarcoma, carcinoma, or melanoma. Diffuse strong positive reaction was observed for CD45, CD20, CD19, CD22, Pax5, and CD30. The case was reported as spindle cell variant of DLBCL based on the present findings. As far as we know, this is the first case described in the colon. We emphasize that pathologists should be reminded of lymphoma as a differential diagnosis of spindle cell tumors.
Identifiants
pubmed: 35013921
doi: 10.1007/s12029-021-00790-z
pii: 10.1007/s12029-021-00790-z
doi:
Types de publication
Review
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
286-289Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Ghimire P, Wu GY, Zhu L. Primary gastrointestinal lymphoma. World J Gastroenterol. 2011;17(6):697–707. https://doi.org/10.3748/wjg.v17.i6.697 .
doi: 10.3748/wjg.v17.i6.697
pubmed: 21390139
pmcid: 3042647
Kluin PM, Slootweg PJ, Schuurman HJ, Go DM, Rademakers LH, van der Putte SC, van Unnik JA. Primary B-cell malignant lymphoma of the maxilla with a sarcomatous pattern and multilobated nuclei. Cancer. 1984;54(8):1598-605. https://doi.org/10.1002/1097-0142(19841015)54:8/1598::aid-cncr2820540822/3.0.co;2-x .
Cerroni L, El-Shabrawi-Caelen L, Fink-Puches R, LeBoit PE, Kerl H. Cutaneous spindle-cell B-cell lymphoma: a morphologic variant of cutaneous large B-cell lymphoma. Am J Dermatopathol. 2000;22(4):299–304. https://doi.org/10.1097/00000372-200008000-00001 .
doi: 10.1097/00000372-200008000-00001
pubmed: 10949453
Wang J, Sun NC, Nozawa Y, Arber DA, Chu P, Chang KL, Weiss LM. Histological and immunohistochemical characterization of extranodal diffuse large-cell lymphomas with prominent spindle cell features. Histopathology. 2001;39(5):476–81. https://doi.org/10.1046/j.1365-2559.2001.01271.x .
doi: 10.1046/j.1365-2559.2001.01271.x
pubmed: 11737305
Kahlifa M, Buckstein R, Perez-Ordoñez B. Sarcomatoid variant of B-cell lymphoma of the uterine cervix. Int J Gynecol Pathol. 2003;22(3):289–93. https://doi.org/10.1097/01.PGP.0000070845.25718.4C .
doi: 10.1097/01.PGP.0000070845.25718.4C
pubmed: 12819398
Li Y, Cui W, Woodroof JM, Zhang D. Extranodal B cell lymphoma with prominent spindle cell features arising in uterus and in maxillary sinus: report of two cases and literature review. Ann Clin Lab Sci. 2016;46(2):213–8.
pubmed: 27098631
Hayashi H, Ohtani H, Ueda T, Yamaguchi J, Izawa K, Hayashida T, Higami Y, Shimokawa I. Primary hepatic lymphoma with spindle cell components: a case report. Virchows Arch. 2006;449(5):591–6. https://doi.org/10.1007/s00428-006-0276-4 .
doi: 10.1007/s00428-006-0276-4
pubmed: 16988839
Zicherman JM, Weissman D, Gribbin C, Epstein R. Best cases from the AFIP: primary diffuse large B-cell lymphoma of the epididymis and testis. Radiographics. 2005;25(1):243–8. https://doi.org/10.1148/rg.251045041 .
doi: 10.1148/rg.251045041
pubmed: 15653598
Satgunaseelan L, Larsen SR, Carmalt H, Cooper WA. Spindle cell variant of diffuse large B cell lymphoma occurring in the breast. Pathology. 2017;49(7):784–6. https://doi.org/10.1016/j.pathol.2017.06.009 .
doi: 10.1016/j.pathol.2017.06.009
pubmed: 29079000
Sugimoto KJ, Shimada A, Ichikawa K, Wakabayashi M, Sekiguchi Y, Izumi H, Ota Y, Komatsu N, Noguchi M. Primary platelet-derived growth factor-producing, spindle-shaped diffuse large B-cell lymphoma of the skull: a case report and literature review. Int J Clin Exp Pathol. 2014;7(7):4381–90.
pubmed: 25120823
pmcid: 4129058
Sukswai N, Lyapichev K, Khoury JD, Medeiros LJ. Diffuse large B-cell lymphoma variants: an update. Pathology. 2020;52(1):53–67. https://doi.org/10.1016/j.pathol.2019.08.013 .
doi: 10.1016/j.pathol.2019.08.013
pubmed: 31735345
Charli-Joseph Y, Cerroni L, LeBoit PE. Cutaneous Spindle-Cell B-Cell Lymphomas: Most are Neoplasms of Follicular Center Cell Origin. Am J Surg Pathol. 2015;39(6):737–43. https://doi.org/10.1097/PAS.0000000000000388 .
doi: 10.1097/PAS.0000000000000388
pubmed: 25634743
Yu L, Yan LL, Yang SJ. Sarcomatoid variant of ALK- anaplastic large cell lymphoma involving multiple lymph nodes and both lungs with production of proinflammatory cytokines: report of a case and review of literature. Int J Clin Exp Pathol. 2014;7(8):4806–16.
pubmed: 25197351
pmcid: 4152041
Swerdlow SH, Campo E, Harris NL. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. Revised 4th edition. IARC, Lyon 2017.
Kimura Y, Arakawa F, Kiyasu J, Miyoshi H, Yoshida M, Ichikawa A, Nakashima S, Ishibashi Y, Niino D, Sugita Y, Ishiyama K, Higuchi M, Takasaki Y, Shimomura T, Koike C, Kuwahara N, Fujikawa K, Ohshima K. A spindle cell variant of diffuse large B-cell lymphoma is characterized by T-cell/myofibrohistio-rich stromal alterations: analysis of 10 cases and a review of the literature. Eur J Haematol. 2012;89(4):302–10. https://doi.org/10.1111/j.1600-0609.2012.01826.x .
doi: 10.1111/j.1600-0609.2012.01826.x
pubmed: 22738254
Virani N, Pang J, Lew M. Cytologic and Immunohistochemical Evaluation of Low-Grade Spindle Cell Lesions of the Gastrointestinal Tract. Arch Pathol Lab Med. 2016;140(10):1038–44. https://doi.org/10.5858/arpa.2016-0235-RA .
doi: 10.5858/arpa.2016-0235-RA
pubmed: 27684974
Ikoma N, Roland CL, Cormier JN, Chiang YJ, Torres KE, Hunt KK, You YN, Feig BW. Nongastrointestinal Stromal Tumor Spindle Cell Sarcomas of the Colon or Rectum. Am Surg. 2018;84(4):570–5.
doi: 10.1177/000313481808400433
pubmed: 29712608