Advances in the Determination of Anabolic-Androgenic Steroids: From Standard Practices to Tailor-Designed Multidisciplinary Approaches.
anabolic-androgenic steroids
antibodies
biosensors
chemically designed sensors
chromatographic detection
fluorescent sensors
immunoassays
immunosensors
oligonucleotide-based approach
specific detection
Journal
Sensors (Basel, Switzerland)
ISSN: 1424-8220
Titre abrégé: Sensors (Basel)
Pays: Switzerland
ID NLM: 101204366
Informations de publication
Date de publication:
21 Dec 2021
21 Dec 2021
Historique:
received:
30
10
2021
revised:
06
12
2021
accepted:
14
12
2021
entrez:
11
1
2022
pubmed:
12
1
2022
medline:
13
1
2022
Statut:
epublish
Résumé
Anabolic-androgenic steroids (AASs), a group of compounds frequently misused by athletes and, unfortunately, also by the general population, have lately attracted global attention; thus, significant demands for more precise, facile, and rapid AAS detection have arisen. The standard methods ordinarily used for AAS determination include liquid and gas chromatography coupled with mass spectrometry. However, good knowledge of steroid metabolism, pretreatment of samples (such as derivatization), and well-trained operators of the instruments are required, making this procedure expensive, complicated, and not routinely applicable. In the drive to meet current AAS detection demands, the scientific focus has shifted to developing novel, tailor-made approaches leading to time- and cost-effective, routine, and field-portable methods for AAS determination in various matrices, such as biological fluids, food supplements, meat, water, or other environmental components. Therefore, herein, we present a comprehensive review article covering recent advances in AAS determination, with a strong emphasis on the increasingly important role of chemically designed artificial sensors, biosensors, and antibody- and fluorescence-based methods.
Identifiants
pubmed: 35009549
pii: s22010004
doi: 10.3390/s22010004
pmc: PMC8747103
pii:
doi:
Substances chimiques
Anabolic Agents
0
Androgens
0
Steroids
0
Testosterone Congeners
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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