Impact of Diabetes and Metformin Use on Enteropancreatic Neuroendocrine Tumors: Post Hoc Analysis of the CLARINET Study.

diabetes mellitus lanreotide progression-free survival

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
23 Dec 2021
Historique:
received: 11 11 2021
revised: 17 12 2021
accepted: 20 12 2021
entrez: 11 1 2022
pubmed: 12 1 2022
medline: 12 1 2022
Statut: epublish

Résumé

The prognostic role of diabetes mellitus (DM) in advanced enteropancreatic neuroendocrine tumors (NETs) is unclear. Progression free survival (PFS) was assessed in post-hoc analyses of the 96-week, phase III, double-blind, placebo-controlled CLARINET study of lanreotide 120 mg in patients with advanced non-functional enteropancreatic NETs with DM (with/without metformin) and without DM. Of 204 patients, there were 79 with DM (lanreotide,

Identifiants

pubmed: 35008233
pii: cancers14010069
doi: 10.3390/cancers14010069
pmc: PMC8750688
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Sara Pusceddu (S)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori (ENETS Center of Excellence), 20133 Milan, Italy.

Claudio Vernieri (C)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori (ENETS Center of Excellence), 20133 Milan, Italy.
IFOM, The FIRC Institute of Molecular Oncology, 20139 Milan, Italy.

Massimo Di Maio (M)

Department of Oncology, University of Turin, A.O. Ordine Mauriziano, 10124 Turin, Italy.

Natalie Prinzi (N)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori (ENETS Center of Excellence), 20133 Milan, Italy.

Martina Torchio (M)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori (ENETS Center of Excellence), 20133 Milan, Italy.

Francesca Corti (F)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori (ENETS Center of Excellence), 20133 Milan, Italy.

Jorgelina Coppa (J)

Department of Gastro-Entero-Pancreatic Surgical and Liver Transplantation, Fondazione IRCCS Istituto Nazionale Tumori (ENETS Center of Excellence), 20133 Milan, Italy.

Roberto Buzzoni (R)

Oncology, Clinica San Carlo Paderno Dugnan, 20037 Milan, Italy.

Maria Di Bartolomeo (M)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori (ENETS Center of Excellence), 20133 Milan, Italy.

Massimo Milione (M)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori (ENETS Center of Excellence), 20133 Milan, Italy.
First Division of Pathology, Department of Pathology and Laboratory Medicine, IRCCS Foundation National Cancer Institute, 20133 Milan, Italy.

Benjamin Regnault (B)

Ipsen, 91940 Les Ulis, Ile-de-France, France.

Xuan-Mai Truong Thanh (XM)

Ipsen, 92100 Boulogne-Billancourt, Ile-de-France, France.

Vincenzo Mazzaferro (V)

Department of Surgery, Fondazione IRCCS Istituto Nazionale Tumori (ENETS Center of Excellence), 20133 Milan, Italy.
Oncology, Università Degli Studi di Milano, 20122 Milan, Italy.

Filippo de Braud (F)

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale Tumori (ENETS Center of Excellence), 20133 Milan, Italy.
Oncology, Università Degli Studi di Milano, 20122 Milan, Italy.

Classifications MeSH