Growth hormone secretagogue receptor deficiency promotes lung cancer growth by affecting the Th17/Treg balance.
Growth hormone secretagogue receptor 1a (GHSR1a)
Th17/Treg balance
lung cancer
microenvironment
tumor immunity
Journal
Annals of translational medicine
ISSN: 2305-5839
Titre abrégé: Ann Transl Med
Pays: China
ID NLM: 101617978
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
22
12
2020
accepted:
19
11
2021
entrez:
6
1
2022
pubmed:
7
1
2022
medline:
7
1
2022
Statut:
ppublish
Résumé
Cluster of differentiation 4 (CD4 A subcutaneous lung cancer model was used to examine the role of GHSR1a in controlling tumor growth. Lewis lung carcinoma (LLC) cells were subcutaneously implanted into We found that the ablation of GHSR1a resulted in impaired anti-tumor immunity to control lung cancer growth Our findings showed the important role of GHSR1a in CD4
Sections du résumé
BACKGROUND
BACKGROUND
Cluster of differentiation 4 (CD4
METHODS
METHODS
A subcutaneous lung cancer model was used to examine the role of GHSR1a in controlling tumor growth. Lewis lung carcinoma (LLC) cells were subcutaneously implanted into
RESULTS
RESULTS
We found that the ablation of GHSR1a resulted in impaired anti-tumor immunity to control lung cancer growth
CONCLUSIONS
CONCLUSIONS
Our findings showed the important role of GHSR1a in CD4
Identifiants
pubmed: 34988205
doi: 10.21037/atm-21-5727
pii: atm-09-22-1696
pmc: PMC8667136
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1696Informations de copyright
2021 Annals of Translational Medicine. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi.org/10.21037/atm-21-5727). The authors have no conflicts of interest to declare.
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