Sequence and functional characterization of a public HIV-specific antibody clonotype.
Immunology
Virology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
21 Jan 2022
21 Jan 2022
Historique:
received:
19
05
2021
revised:
30
08
2021
accepted:
01
12
2021
entrez:
5
1
2022
pubmed:
6
1
2022
medline:
6
1
2022
Statut:
epublish
Résumé
Public antibody clonotypes shared among multiple individuals have been identified for several pathogens. However, little is known about the determinants of antibody "publicness". Here, we characterize the sequence and functional properties of antibodies from a public clonotype targeting the CD4 binding site on HIV-1 Env. Our results showed that HIV-1 specificity for the public antibodies studied here, comprising sequences from three individuals, was modulated by the V
Identifiants
pubmed: 34984325
doi: 10.1016/j.isci.2021.103564
pii: S2589-0042(21)01534-0
pmc: PMC8692997
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103564Subventions
Organisme : NIAID NIH HHS
ID : P30 AI110527
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI131722
Pays : United States
Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
I.S.G. is a co-founder of AbSeek Bio. I.S., L.M., and I.S.G. are listed as inventors on patents filed for the antibodies described here. The Georgiev laboratory at Vanderbilt University Medical Center has received unrelated funding from Takeda Pharmaceuticals.
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