2022 European Thyroid Association Guideline for the management of pediatric Graves' disease.
Graves’ disease
antithyroid drugs
childhood
clinical practice guideline
management
pediatric
radioactive iodine
total thyroidectomy
Journal
European thyroid journal
ISSN: 2235-0640
Titre abrégé: Eur Thyroid J
Pays: England
ID NLM: 101604579
Informations de publication
Date de publication:
01 01 2022
01 01 2022
Historique:
received:
27
10
2021
accepted:
04
11
2021
entrez:
4
1
2022
pubmed:
5
1
2022
medline:
5
1
2022
Statut:
epublish
Résumé
Hyperthyroidism caused by Graves' disease (GD) is a relatively rare disease in children. Treatment options are the same as in adults - antithyroid drugs (ATD), radioactive iodine (RAI) or thyroid surgery, but the risks and benefits of each modality are different. The European Thyroid Association guideline provides new recommendations for the management of pediatric GD with and without orbitopathy. Clinicians should be alert that GD may present with behavioral changes or declining academic performance in children. Measurement of serum TSH receptor antibodies is recommended for all pediatric patients with hyperthyroidism. Management recommendations include the first-line use of a prolonged course of methimazole/carbimazole ATD treatment (3 years or more), a preference for dose titration instead of block and replace ATD, and to avoid propylthiouracil use. Where definitive treatment is required either total thyroidectomy or RAI is recommended, aiming for complete thyroid ablation with a personalized RAI activity. We recommend avoiding RAI in children under 10 years of age but favor surgery in patients with large goiter. Pediatric endocrinologists should be involved in all cases.
Identifiants
pubmed: 34981748
doi: 10.1530/ETJ-21-0073
pii: e210073
pmc: PMC9142815
doi:
pii:
Types de publication
Guideline
Langues
eng
Subventions
Organisme : Medical Research Council
ID : G0500783
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/V005898/1
Pays : United Kingdom
Références
Surg Today. 2006;36(2):125-30
pubmed: 16440157
Thyroid. 2013 Aug;23(8):1010-4
pubmed: 23556479
Int J Pediatr Endocrinol. 2014;2014(1):10
pubmed: 25089127
Eur Thyroid J. 2018 Aug;7(4):167-186
pubmed: 30283735
Trans Am Ophthalmol Soc. 2007;105:146-50; discussion 150-1
pubmed: 18427604
J Clin Endocrinol Metab. 2020 Sep 1;105(9):
pubmed: 32501499
J Clin Endocrinol Metab. 2018 Aug 1;103(8):2918-2925
pubmed: 29788090
Int J Endocrinol. 2017;2017:2619695
pubmed: 29403532
N Engl J Med. 2011 May 19;364(20):1920-31
pubmed: 21591944
J Mol Endocrinol. 2011 Apr 12;46(3):155-63
pubmed: 21321093
JAMA Pediatr. 2016 Oct 01;170(10):1008-1019
pubmed: 27571216
J Endocr Soc. 2017 Feb 15;1(3):231-236
pubmed: 29264480
Orbit. 2014 Apr;33(2):96-103
pubmed: 24206067
Thyroid. 1997 Oct;7(5):755-60
pubmed: 9349579
N Engl J Med. 2016 Oct 20;375(16):1552-1565
pubmed: 27797318
Endocrine. 2020 May;68(2):261-264
pubmed: 32472423
Thyroid. 2008 Sep;18(9):997-9
pubmed: 18713025
Eur J Endocrinol. 2007 Jan;156(1):33-40
pubmed: 17218723
J Ophthalmol. 2017;2017:4853905
pubmed: 29225963
Clin Endocrinol (Oxf). 1984 Aug;21(2):163-72
pubmed: 6205795
J Clin Endocrinol Metab. 2011 Oct;96(10):3257-63
pubmed: 21849528
Clin Endocrinol (Oxf). 2021 Feb;94(2):330-340
pubmed: 33128233
Eur J Endocrinol. 2017 Aug;177(2):R59-R67
pubmed: 28381452
Clin Endocrinol (Oxf). 2001 Apr;54(4):547-50
pubmed: 11318792
J Clin Endocrinol Metab. 2000 Oct;85(10):3678-82
pubmed: 11061522
J Pediatr Endocrinol Metab. 2014 Nov;27(11-12):1131-6
pubmed: 24945422
J Clin Endocrinol Metab. 2007 Mar;92(3):797-800
pubmed: 17341574
Eur J Endocrinol. 2011 Dec;165(6):899-905
pubmed: 21908653
Clin Endocrinol (Oxf). 2019 Feb;90(2):320-327
pubmed: 30358895
Experientia. 1995 Dec 18;51(12):1208-15
pubmed: 8536808
J Surg Res. 2000 May 15;90(2):161-5
pubmed: 10792958
J Clin Endocrinol Metab. 2008 Oct;93(10):3817-26
pubmed: 18628515
Eur J Nucl Med Mol Imaging. 2010 Nov;37(11):2218-28
pubmed: 20625722
J Clin Endocrinol Metab. 1990 Apr;70(4):830-5
pubmed: 2180978
J Autoimmun. 2015 Nov;64:82-90
pubmed: 26235382
J Clin Invest. 1979 Nov;64(5):1429-36
pubmed: 91625
World J Surg. 2012 Aug;36(8):1943-6
pubmed: 22547016
Eur J Endocrinol. 2020 Dec;183(6):637-645
pubmed: 33107439
J Clin Endocrinol Metab. 2007 May;92(5):1769-72
pubmed: 17284622
Clin Endocrinol (Oxf). 2010 Mar;72(3):358-63
pubmed: 19769613
J Clin Endocrinol Metab. 2008 Mar;93(3):666-73
pubmed: 18171699
J Pediatr Endocrinol Metab. 2016 Oct 1;29(10):1115-1122
pubmed: 27682712
Eur Thyroid J. 2021 Mar;10(1):39-51
pubmed: 33777818
J Clin Endocrinol Metab. 2000 Mar;85(3):1038-42
pubmed: 10720036
Int J Pediatr Endocrinol. 2010;2010:176970
pubmed: 20224800
Autoimmunity. 2018 Jun;51(4):183-190
pubmed: 29973096
J Pediatr Ophthalmol Strabismus. 1979 Mar-Apr;16(2):105-7
pubmed: 458514
Br J Ophthalmol. 2002 Jul;86(7):740-2
pubmed: 12084741
J Clin Endocrinol Metab. 2014 May;99(5):1648-55
pubmed: 24517152
Cancer Manag Res. 2018 May 21;10:1201-1207
pubmed: 29872340
Nat Rev Dis Primers. 2020 Jul 2;6(1):52
pubmed: 32616746
J AAPOS. 2008 Aug;12(4):357-60
pubmed: 18359653
Gland Surg. 2017 Oct;6(5):552-562
pubmed: 29142848
Acta Paediatr. 1999 Sep;88(9):937-41
pubmed: 10519332
Front Endocrinol (Lausanne). 2020 Oct 23;11:544658
pubmed: 33193078
J Clin Endocrinol Metab. 1995 Apr;80(4):1083-5
pubmed: 7714072
J Clin Endocrinol Metab. 2004 Sep;89(9):4229-33
pubmed: 15356012
Int J Endocrinol. 2016;2016:8129497
pubmed: 27413373
Best Pract Res Clin Endocrinol Metab. 2018 Aug;32(4):373-386
pubmed: 30086864
J Endocrinol Invest. 2020 May;43(5):595-600
pubmed: 31713721
Ophthalmic Plast Reconstr Surg. 2006 Jan-Feb;22(1):7-12
pubmed: 16418658
J Clin Endocrinol Metab. 2012 Jan;97(1):110-9
pubmed: 22031519
Ann Intern Med. 1989 Jul 15;111(2):181-2
pubmed: 2742250
J Clin Endocrinol Metab. 1997 Jun;82(6):1719-26
pubmed: 9177370
Pharmacol Ther. 2020 May;209:107502
pubmed: 32061922
Eur Thyroid J. 2019 Jul;8(4):196-201
pubmed: 31602362
Intern Med. 2012;51(17):2285-90
pubmed: 22975536
Best Pract Res Clin Endocrinol Metab. 2020 Jul;34(4):101437
pubmed: 32651060
Eur Thyroid J. 2016 Mar;5(1):9-26
pubmed: 27099835
Cochrane Database Syst Rev. 2008 Jul 16;(3):CD006294
pubmed: 18646146
Horm Metab Res. 2012 Apr;44(4):255-62
pubmed: 22334393
Eur J Endocrinol. 2008 Nov;159(5):609-15
pubmed: 18628345
Endocrinol Metab (Seoul). 2019 Mar;34(1):29-38
pubmed: 30912336
Am J Case Rep. 2014 May 14;15:212-5
pubmed: 24847412
J Clin Endocrinol Metab. 1986 Jul;63(1):125-8
pubmed: 3011835
Exp Clin Endocrinol Diabetes. 1999;107 Suppl 5:S172-4
pubmed: 10614915
Thyroid. 2006 Jul;16(7):709-10
pubmed: 16889501
Thyroid. 2014 Feb;24(2):200-7
pubmed: 23926918
Endocr Pract. 2020 Jul;26(7):729-737
pubmed: 33471641
Clin Endocrinol (Oxf). 2014 Oct;81(4):610-3
pubmed: 24801484
Eur J Endocrinol. 2006 Apr;154(4):511-7
pubmed: 16556712
Horm Res Paediatr. 2019;91(3):195-202
pubmed: 31096231
Eur J Endocrinol. 2015 Jun;172(6):715-23
pubmed: 25766047
Am J Med. 2010 Feb;123(2):183.e1-9
pubmed: 20103030
Endocr Pract. 2019 Dec;25(12):1323-1337
pubmed: 31412224
J Nucl Med. 2012 Oct;53(10):1633-51
pubmed: 22787108
Lancet. 2016 Aug 27;388(10047):906-918
pubmed: 27038492
Ophthalmic Plast Reconstr Surg. 2017 May/Jun;33(3S Suppl 1):S186-S188
pubmed: 26524159
Arch Ophthalmol. 1980 Nov;98(11):1963-4
pubmed: 6893665
J Endocrinol Invest. 2020 Jan;43(1):109-116
pubmed: 31327128
BMJ Open. 2019 Jan 21;9(1):e024705
pubmed: 30670519
Eur Thyroid J. 2021 Jul;10(5):353-363
pubmed: 34540705
Pediatrics. 2019 May;143(5):
pubmed: 31040197
Ophthalmic Plast Reconstr Surg. 2018 Jul/Aug;34(4S Suppl 1):S52-S55
pubmed: 29985836
Horm Res Paediatr. 2015 Apr 15;:
pubmed: 25896059
J Clin Endocrinol Metab. 2018 Aug 1;103(8):2980-2987
pubmed: 29846622
Clin Endocrinol (Oxf). 2004 Nov;61(5):589-94
pubmed: 15521961
Clin Endocrinol (Oxf). 2016 Dec;85(6):949-953
pubmed: 27291145
Acc Chem Res. 2013 Nov 19;46(11):2706-15
pubmed: 23883148
Eur J Endocrinol. 2021 Jul 07;185(2):219-229
pubmed: 34061770
J Otolaryngol Head Neck Surg. 2018 Jan 22;47(1):6
pubmed: 29357932
J Pediatr. 2014 May;164(5):1189-1194.e1
pubmed: 24518168
N Engl J Med. 2009 Apr 9;360(15):1574-5
pubmed: 19357418