Coupling immuno-magnetic capture with LC-MS/MS(MRM) as a sensitive, reliable, and specific assay for SARS-CoV-2 identification from clinical samples.
Amino Acid Sequence
Antibodies, Viral
/ chemistry
Biomarkers
/ chemistry
COVID-19
/ diagnosis
COVID-19 Testing
/ instrumentation
Chromatography, Liquid
/ instrumentation
Humans
Immunomagnetic Separation
/ instrumentation
Nasopharynx
/ virology
Peptides
/ chemistry
SARS-CoV-2
/ genetics
Sensitivity and Specificity
Tandem Mass Spectrometry
/ instrumentation
Clinical samples
Immunomagnetic capture
LC–MS/MS(MRM)
SARS-CoV-2
Signal to noise ratio
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Feb 2022
Feb 2022
Historique:
received:
30
09
2021
accepted:
03
12
2021
revised:
21
11
2021
pubmed:
5
1
2022
medline:
3
2
2022
entrez:
4
1
2022
Statut:
ppublish
Résumé
Recently, numerous diagnostic approaches from different disciplines have been developed for SARS-CoV-2 diagnosis to monitor and control the COVID-19 pandemic. These include MS-based assays, which provide analytical information on viral proteins. However, their sensitivity is limited, estimated to be 5 × 10
Identifiants
pubmed: 34981149
doi: 10.1007/s00216-021-03831-5
pii: 10.1007/s00216-021-03831-5
pmc: PMC8723902
doi:
Substances chimiques
Antibodies, Viral
0
Biomarkers
0
Peptides
0
Types de publication
Journal Article
Validation Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
1949-1962Informations de copyright
© 2021. Springer-Verlag GmbH Germany, part of Springer Nature.
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