Adjuvant therapy with 1% alendronate gel for experimental periodontitis treatment in rats.
Alendronate
Dental scaling
Periodontal disease
Periodontitis
Rats
Journal
Journal of periodontal & implant science
ISSN: 2093-2278
Titre abrégé: J Periodontal Implant Sci
Pays: Korea (South)
ID NLM: 101526931
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
03
02
2021
revised:
12
04
2021
accepted:
10
05
2021
entrez:
29
12
2021
pubmed:
30
12
2021
medline:
30
12
2021
Statut:
ppublish
Résumé
The aim of this study was to evaluate the effects of locally delivered 1% alendronate (ALN) gel used as an adjunct to non-invasive periodontal therapy. Ligature-induced periodontitis was performed in 96 rats. The ligature was tied in the cervical area of the mandibular left first molar. The animals were randomly divided into 4 groups: 1) NT, no treatment; 2) SRP, scaling and root planning; 3) SRP/PLA, SRP followed by filling the periodontal pocket with placebo gel (PLA); and 4) SRP/ALN, SRP followed by filling the periodontal pockets with 1% ALN gel. Histomorphometric (percentage of bone in the furcation region [PBF]) and immunohistochemical (receptor activator of nuclear factor-κB ligand, osteoprotegerin, and tartrate-resistant acid phosphatase) analyses were performed. Data were statistically analyzed, with the threshold of statistical significance set at The SRP, SRP/PLA, and SRP/ALN groups presented a higher PBF than the NT group ( Locally delivered 1% ALN gel used as an adjunct to SRP enhanced bone regeneration in the furcation region in a rat model of experimental periodontitis.
Identifiants
pubmed: 34965617
pii: 51.374
doi: 10.5051/jpis.2100700035
pmc: PMC8718338
doi:
Types de publication
Journal Article
Langues
eng
Pagination
374-385Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado de São Paulo
ID : #18/03331-1
Pays : Brazil
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Pays : Brazil
Informations de copyright
Copyright © 2021. Korean Academy of Periodontology.
Déclaration de conflit d'intérêts
No potential conflict of interest relevant to this article was reported.
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