9-ING-41, a Small Molecule Inhibitor of GSK-3β, Potentiates the Effects of Chemotherapy on Colorectal Cancer Cells.

9-ING-41 GSK-3 KRAS cell cycle colorectal cancer tumor organoids

Journal

Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923

Informations de publication

Date de publication:
2021
Historique:
received: 14 09 2021
accepted: 08 11 2021
entrez: 27 12 2021
pubmed: 28 12 2021
medline: 28 12 2021
Statut: epublish

Résumé

Colorectal cancer (CRC) is one of the most common and lethal types of cancer. Although researchers have made significant efforts to study the mechanisms underlying CRC drug resistance, our knowledge of this disease is still limited, and novel therapies are in high demand. It is urgent to find new targeted therapy considering limited chemotherapy options.

Identifiants

DOI: 10.3389/fphar.2021.777114 PMID: 34955846 PMC: PMC8696016
pubmed: 34955846
doi: 10.3389/fphar.2021.777114
pii: 777114
pmc: PMC8696016
doi:

Types de publication

Journal Article

Langues

eng

Pagination

777114

Informations de copyright

Copyright © 2021 Poloznikov, Nikulin, Bolotina, Kachmazov, Raigorodskaya, Kudryavtseva, Bakhtogarimov, Rodin, Gaisina, Topchiy, Asachenko, Novosad, Tonevitsky and Alekseev.

Déclaration de conflit d'intérêts

IG is a co-inventor on the 9-ING-41 patent. All other authors declare no conflict of interest.

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Auteurs

Andrey Poloznikov (A)

Faculty of Biology and Biotechnologies, Higher School of Economics, Moscow, Russia.
P. Hertsen Moscow Oncology Research Institute-Branch of the National Medical Research Radiological Centre of the Ministry of Health of Russian Federation, Moscow, Russia.

Sergey Nikulin (S)

Faculty of Biology and Biotechnologies, Higher School of Economics, Moscow, Russia.
P. Hertsen Moscow Oncology Research Institute-Branch of the National Medical Research Radiological Centre of the Ministry of Health of Russian Federation, Moscow, Russia.
School of Biomedicine, Far Eastern Federal University, Vladivostok, Russia.

Larisa Bolotina (L)

P. Hertsen Moscow Oncology Research Institute-Branch of the National Medical Research Radiological Centre of the Ministry of Health of Russian Federation, Moscow, Russia.

Andrei Kachmazov (A)

P. Hertsen Moscow Oncology Research Institute-Branch of the National Medical Research Radiological Centre of the Ministry of Health of Russian Federation, Moscow, Russia.

Maria Raigorodskaya (M)

Scientific Research Centre Bioclinicum, Moscow, Russia.

Anna Kudryavtseva (A)

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

Ildar Bakhtogarimov (I)

Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia.

Sergey Rodin (S)

Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.

Irina Gaisina (I)

Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago, IL, United States.

Maxim Topchiy (M)

A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russia.

Andrey Asachenko (A)

A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russia.

Victor Novosad (V)

Laboratory of Microfluidic Technologies for Biomedicine, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.

Alexander Tonevitsky (A)

Faculty of Biology and Biotechnologies, Higher School of Economics, Moscow, Russia.
Scientific Research Centre Bioclinicum, Moscow, Russia.
Laboratory of Microfluidic Technologies for Biomedicine, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia.

Boris Alekseev (B)

P. Hertsen Moscow Oncology Research Institute-Branch of the National Medical Research Radiological Centre of the Ministry of Health of Russian Federation, Moscow, Russia.

Classifications MeSH