Structural MRI-Based Measures of Accelerated Brain Aging do not Moderate the Acute Antidepressant Response in Late-Life Depression.

Aging / psychology Antidepressive Agents / therapeutic use Brain / diagnostic imaging Bupropion Depression / psychology Humans Magnetic Resonance Imaging / methods
Depression MRI aging antidepressant clinical trial machine learning structural neuroimaging

Journal

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
ISSN: 1545-7214
Titre abrégé: Am J Geriatr Psychiatry
Pays: England
ID NLM: 9309609

Informations de publication

Date de publication:
09 2022
Historique:
received: 08 09 2021
revised: 14 11 2021
accepted: 21 11 2021
pubmed: 25 12 2021
medline: 10 8 2022
entrez: 24 12 2021
Statut: ppublish

Résumé

Late-life depression (LLD) is characterized by accelerated biological aging. Accelerated brain aging, estimated from structural magnetic resonance imaging (sMRI) data by a machine learning algorithm, is associated with LLD diagnosis, poorer cognitive performance, and disability. We hypothesized that accelerated brain aging moderates the antidepressant response. Following MRI, participants entered an 8-week randomized, controlled trial of escitalopram. Nonremitting participants then entered an open-label 8-week trial of bupropion. Ninety-five individuals with LLD. A machine learning algorithm estimated each participant's brain age from sMRI data. This was used to calculate the brain-age gap (BAG), or how estimated age differed from chronological age. Secondary sMRI measures of aging pathology included white matter hyperintensity (WMH) volumes and hippocampal volumes. Mixed models examined the relationship between sMRI measures and change in depression severity. Initial analyses tested for a moderating effect of MRI measures on change in depression severity with escitalopram. Subsequent analyses tested for the effect of MRI measures on change in depression severity over time across trials. In the blinded initial phase, BAG was not significantly associated with a differential response to escitalopram over time. BAG was also not associated with a change in depression severity over time across both arms in the blinded phase or in the subsequent open-label bupropion phase. We similarly did not observe effects of WMH volume or hippocampal volume on change in depression severity over time. sMRI markers of accelerated brain aging were not associated with treatment response in this sequential antidepressant trial.

Identifiants

DOI: 10.1016/j.jagp.2021.11.011 PMID: 34949526 PMC: PMC9142760
pubmed: 34949526
pii: S1064-7481(21)00550-9
doi: 10.1016/j.jagp.2021.11.011
pmc: PMC9142760
mid: NIHMS1766475
pii:
doi:

Substances chimiques

Antidepressive Agents 0
Bupropion 01ZG3TPX31

Types de publication

Journal Article Randomized Controlled Trial Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1015-1025

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR000445
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH102246
Pays : United States
Organisme : NIH HHS
ID : S10 OD021771
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007347
Pays : United States
Organisme : NIMH NIH HHS
ID : K24 MH110598
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002243
Pays : United States

Informations de copyright

Published by Elsevier Inc.

Références

J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538
Psychosom Med. 2016 Sep;78(7):776-87
pubmed: 27359174
Am J Geriatr Psychiatry. 2002 Jan-Feb;10(1):107-11
pubmed: 11790641
Biol Psychiatry. 2000 Aug 15;48(4):301-9
pubmed: 10960161
Magn Reson Imaging. 2019 Oct;62:70-77
pubmed: 31247249
Psychol Med. 2020 Jan;50(2):187-209
pubmed: 31858931
Am J Geriatr Psychiatry. 2014 Dec;22(12):1504-12
pubmed: 24378256
Am J Psychiatry. 2004 Nov;161(11):2081-90
pubmed: 15514410
Neuroimage. 2004;23 Suppl 1:S69-84
pubmed: 15501102
J Neurophysiol. 2006 Dec;96(6):2830-9
pubmed: 17110737
Neuroimage. 2012 Feb 15;59(4):3774-83
pubmed: 22119648
Arch Gen Psychiatry. 2010 Mar;67(3):277-85
pubmed: 20194828
Br J Psychiatry. 2013 May;202(5):329-35
pubmed: 23637108
Am J Psychiatry. 2017 Mar 1;174(3):237-245
pubmed: 27539488
Neurology. 2000 Aug 22;55(4):484-89
pubmed: 10953178
Dis Markers. 2013;35(1):23-31
pubmed: 24167346
Curr Opin Psychiatry. 2019 Sep;32(5):381-387
pubmed: 31145144
Br J Psychiatry. 1979 Apr;134:382-9
pubmed: 444788
Eur Neuropsychopharmacol. 2012 Jan;22(1):1-16
pubmed: 21723712
Mol Psychiatry. 2017 Mar;22(3):450-457
pubmed: 27090303
Biol Psychiatry Cogn Neurosci Neuroimaging. 2019 Feb;4(2):160-170
pubmed: 30392844
Transl Psychiatry. 2020 Sep 18;10(1):317
pubmed: 32948749
Mol Psychiatry. 2021 Jul;26(7):3646-3656
pubmed: 32632206
Am J Geriatr Psychiatry. 2007 Jul;15(7):553-63
pubmed: 17586780
Am J Geriatr Psychiatry. 2019 Dec;27(12):1316-1330
pubmed: 31477459
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Mol Psychiatry. 2013 Sep;18(9):963-74
pubmed: 23439482
Mol Neuropsychiatry. 2016 Jul;2(2):88-96
pubmed: 27429957
Am J Geriatr Psychiatry. 2013 Feb;21(2):184-95
pubmed: 23343492
Cereb Cortex. 2004 Jan;14(1):11-22
pubmed: 14654453
IEEE Trans Med Imaging. 2010 Jun;29(6):1310-20
pubmed: 20378467
J Affect Disord. 2010 Nov;126(3):395-401
pubmed: 20452031
Am J Geriatr Psychiatry. 2021 May;29(5):448-457
pubmed: 33032927
Aging Cell. 2017 Aug;16(4):624-633
pubmed: 28544158
Int J Geriatr Psychiatry. 2002 Jun;17(6):519-25
pubmed: 12112175
J Affect Disord. 2015 Jul 15;180:200-6
pubmed: 25913805
Am J Geriatr Psychiatry. 2011 Jan;19(1):4-12
pubmed: 20808107
World J Biol Psychiatry. 2018 Aug;19(5):360-367
pubmed: 27376473
Neuroimage. 2019 Oct 15;200:528-539
pubmed: 31201988
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
Med Image Anal. 2014 Oct;18(7):1070-81
pubmed: 25033470
J Affect Disord. 2017 Jun;215:103-110
pubmed: 28324779
Psychiatry Res. 2005 May 30;139(1):1-7
pubmed: 15927454
J Gerontol A Biol Sci Med Sci. 2017 Mar 1;72(3):343-352
pubmed: 27994004
Neuropsychopharmacology. 2020 Jan;45(2):283-291
pubmed: 31610545

Auteurs

Ryan Ahmed (R)

School of Medicine (RA), Vanderbilt University, Nashville, TN; Department of Psychiatry and Behavioral Sciences (SC, DE, BAL, SMS, BDB, WDT), Vanderbilt University Medical Center, Nashville, TN; Department of Biomedical Engineering (CB, BAL), Vanderbilt University, Nashville TN; Department of Electrical Engineering and Computer Science (BAL), Vanderbilt University, Nashville, TN; Department of Biostatistics (HK), Vanderbilt University Medical Center, Nashville, TN; Geriatric Research, Education, and Clinical Center (WDT), Veterans Affairs Tennessee Valley Health System, Nashville, TN.

Claire Ryan (C)

School of Medicine (RA), Vanderbilt University, Nashville, TN; Department of Psychiatry and Behavioral Sciences (SC, DE, BAL, SMS, BDB, WDT), Vanderbilt University Medical Center, Nashville, TN; Department of Biomedical Engineering (CB, BAL), Vanderbilt University, Nashville TN; Department of Electrical Engineering and Computer Science (BAL), Vanderbilt University, Nashville, TN; Department of Biostatistics (HK), Vanderbilt University Medical Center, Nashville, TN; Geriatric Research, Education, and Clinical Center (WDT), Veterans Affairs Tennessee Valley Health System, Nashville, TN.

Seth Christman (S)

School of Medicine (RA), Vanderbilt University, Nashville, TN; Department of Psychiatry and Behavioral Sciences (SC, DE, BAL, SMS, BDB, WDT), Vanderbilt University Medical Center, Nashville, TN; Department of Biomedical Engineering (CB, BAL), Vanderbilt University, Nashville TN; Department of Electrical Engineering and Computer Science (BAL), Vanderbilt University, Nashville, TN; Department of Biostatistics (HK), Vanderbilt University Medical Center, Nashville, TN; Geriatric Research, Education, and Clinical Center (WDT), Veterans Affairs Tennessee Valley Health System, Nashville, TN.

Damian Elson (D)

School of Medicine (RA), Vanderbilt University, Nashville, TN; Department of Psychiatry and Behavioral Sciences (SC, DE, BAL, SMS, BDB, WDT), Vanderbilt University Medical Center, Nashville, TN; Department of Biomedical Engineering (CB, BAL), Vanderbilt University, Nashville TN; Department of Electrical Engineering and Computer Science (BAL), Vanderbilt University, Nashville, TN; Department of Biostatistics (HK), Vanderbilt University Medical Center, Nashville, TN; Geriatric Research, Education, and Clinical Center (WDT), Veterans Affairs Tennessee Valley Health System, Nashville, TN.

Camilo Bermudez (C)

School of Medicine (RA), Vanderbilt University, Nashville, TN; Department of Psychiatry and Behavioral Sciences (SC, DE, BAL, SMS, BDB, WDT), Vanderbilt University Medical Center, Nashville, TN; Department of Biomedical Engineering (CB, BAL), Vanderbilt University, Nashville TN; Department of Electrical Engineering and Computer Science (BAL), Vanderbilt University, Nashville, TN; Department of Biostatistics (HK), Vanderbilt University Medical Center, Nashville, TN; Geriatric Research, Education, and Clinical Center (WDT), Veterans Affairs Tennessee Valley Health System, Nashville, TN.

Bennett A Landman (BA)

School of Medicine (RA), Vanderbilt University, Nashville, TN; Department of Psychiatry and Behavioral Sciences (SC, DE, BAL, SMS, BDB, WDT), Vanderbilt University Medical Center, Nashville, TN; Department of Biomedical Engineering (CB, BAL), Vanderbilt University, Nashville TN; Department of Electrical Engineering and Computer Science (BAL), Vanderbilt University, Nashville, TN; Department of Biostatistics (HK), Vanderbilt University Medical Center, Nashville, TN; Geriatric Research, Education, and Clinical Center (WDT), Veterans Affairs Tennessee Valley Health System, Nashville, TN.

Sarah M Szymkowicz (SM)

School of Medicine (RA), Vanderbilt University, Nashville, TN; Department of Psychiatry and Behavioral Sciences (SC, DE, BAL, SMS, BDB, WDT), Vanderbilt University Medical Center, Nashville, TN; Department of Biomedical Engineering (CB, BAL), Vanderbilt University, Nashville TN; Department of Electrical Engineering and Computer Science (BAL), Vanderbilt University, Nashville, TN; Department of Biostatistics (HK), Vanderbilt University Medical Center, Nashville, TN; Geriatric Research, Education, and Clinical Center (WDT), Veterans Affairs Tennessee Valley Health System, Nashville, TN.

Brian D Boyd (BD)

School of Medicine (RA), Vanderbilt University, Nashville, TN; Department of Psychiatry and Behavioral Sciences (SC, DE, BAL, SMS, BDB, WDT), Vanderbilt University Medical Center, Nashville, TN; Department of Biomedical Engineering (CB, BAL), Vanderbilt University, Nashville TN; Department of Electrical Engineering and Computer Science (BAL), Vanderbilt University, Nashville, TN; Department of Biostatistics (HK), Vanderbilt University Medical Center, Nashville, TN; Geriatric Research, Education, and Clinical Center (WDT), Veterans Affairs Tennessee Valley Health System, Nashville, TN.

Hakmook Kang (H)

School of Medicine (RA), Vanderbilt University, Nashville, TN; Department of Psychiatry and Behavioral Sciences (SC, DE, BAL, SMS, BDB, WDT), Vanderbilt University Medical Center, Nashville, TN; Department of Biomedical Engineering (CB, BAL), Vanderbilt University, Nashville TN; Department of Electrical Engineering and Computer Science (BAL), Vanderbilt University, Nashville, TN; Department of Biostatistics (HK), Vanderbilt University Medical Center, Nashville, TN; Geriatric Research, Education, and Clinical Center (WDT), Veterans Affairs Tennessee Valley Health System, Nashville, TN.

Warren D Taylor (WD)

School of Medicine (RA), Vanderbilt University, Nashville, TN; Department of Psychiatry and Behavioral Sciences (SC, DE, BAL, SMS, BDB, WDT), Vanderbilt University Medical Center, Nashville, TN; Department of Biomedical Engineering (CB, BAL), Vanderbilt University, Nashville TN; Department of Electrical Engineering and Computer Science (BAL), Vanderbilt University, Nashville, TN; Department of Biostatistics (HK), Vanderbilt University Medical Center, Nashville, TN; Geriatric Research, Education, and Clinical Center (WDT), Veterans Affairs Tennessee Valley Health System, Nashville, TN. Electronic address: warren.d.taylor@vanderbilt.edu.

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