Recent Advances in Diagnosis and Therapy of Angioimmunoblastic T Cell Lymphoma.
angioimmunoblastic T cell lymphoma
diagnosis
therapy
Journal
Current oncology (Toronto, Ont.)
ISSN: 1718-7729
Titre abrégé: Curr Oncol
Pays: Switzerland
ID NLM: 9502503
Informations de publication
Date de publication:
20 12 2021
20 12 2021
Historique:
received:
25
10
2021
revised:
09
12
2021
accepted:
17
12
2021
entrez:
23
12
2021
pubmed:
24
12
2021
medline:
25
3
2022
Statut:
epublish
Résumé
Angioimmunoblastic T cell lymphoma (AITL) is a common subtype of mature peripheral T cell lymphoma (PTCL). As per the 2016 World Health Organization classification, AITL is now considered as a subtype of nodal T cell lymphoma with follicular helper T cells. The diagnosis is challenging and requires a constellation of clinical, laboratory and histopathological findings. Significant progress in the molecular pathophysiology of AITL has been achieved in the past two decades. Characteristic genomic features have been recognized that could provide a potential platform for better diagnosis and future prognostic models. Frontline therapy for AITL was mainly depending on chemotherapy and the management of relapsed or refractory AITL is still unsatisfactory with a very poor prognosis. Upfront transplantation offers better survival. Novel agents have been introduced recently with promising outcomes. Several clinical trials of combinations using novel agents are underway. Herein, we briefly review recent advances in AITL diagnosis and the evolving treatment landscape.
Identifiants
pubmed: 34940095
pii: curroncol28060456
doi: 10.3390/curroncol28060456
pmc: PMC8699908
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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