Genetic analysis of praziquantel response in schistosome parasites implicates a transient receptor potential channel.

Animals Anthelmintics / pharmacology Genome-Wide Association Study Parasites / metabolism Praziquantel / pharmacology Schistosomiasis mansoni / drug therapy Transient Receptor Potential Channels / metabolism

Journal

Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086

Informations de publication

Date de publication:
22 12 2021
Historique:
entrez: 22 12 2021
pubmed: 23 12 2021
medline: 1 4 2022
Statut: ppublish

Résumé

Mass drug administration with praziquantel (PZQ) monotherapy is considered the mainstay for control and elimination of the parasites causing schistosomiasis in humans. This drug shows imperfect cure rates in the field, and parasites showing reduced PZQ response can be selected in the laboratory, but the extent of resistance in

Identifiants

DOI: 10.1126/scitranslmed.abj9114 PMID: 34936381 PMC: PMC9491494
pubmed: 34936381
doi: 10.1126/scitranslmed.abj9114
pmc: PMC9491494
mid: NIHMS1832886
doi:

Substances chimiques

Anthelmintics 0
Transient Receptor Potential Channels 0
Praziquantel 6490C9U457

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabj9114

Subventions

Organisme : NCRR NIH HHS
ID : C06 RR013556
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI133749
Pays : United States
Organisme : Wellcome Trust
ID : 104958/Z/14/Z
Pays : United Kingdom
Organisme : NIH HHS
ID : P51 OD011133
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI145871
Pays : United States
Organisme : World Health Organization
ID : 001
Pays : International
Organisme : NIAID NIH HHS
ID : R01 AI123434
Pays : United States

Commentaires et corrections

Type : CommentIn

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Auteurs

Winka Le Clec'h (W)

Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
ORCID: 0000-0002-1111-2492

Frédéric D Chevalier (FD)

Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
ORCID: 0000-0003-2611-8106

Ana Carolina A Mattos (ACA)

University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
ORCID: 0000-0003-1903-7615

Amanda Strickland (A)

Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
ORCID: 0000-0001-5839-2391

Robbie Diaz (R)

Texas Biomedical Research Institute, San Antonio, TX 78227, USA.

Marina McDew-White (M)

Texas Biomedical Research Institute, San Antonio, TX 78227, USA.

Claudia M Rohr (CM)

Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
ORCID: 0000-0003-0065-7160

Safari Kinung'hi (S)

National Institute for Medical Research, Mwanza, United Republic of Tanzania.

Fiona Allan (F)

London Centre for Neglected Tropical Disease Research (LCNDTR), Imperial College, London, UK.
Wolfson Wellcome Biomedical Laboratories, Natural History Museum, London, UK.
ORCID: 0000-0001-6836-4124

Bonnie L Webster (BL)

London Centre for Neglected Tropical Disease Research (LCNDTR), Imperial College, London, UK.
Wolfson Wellcome Biomedical Laboratories, Natural History Museum, London, UK.
ORCID: 0000-0003-0930-9314

Joanne P Webster (JP)

London Centre for Neglected Tropical Disease Research (LCNDTR), Imperial College, London, UK.
Centre for Emerging, Endemic and Exotic Diseases (CEEED), Royal Veterinary College, University of London, London, UK.
ORCID: 0000-0001-8616-4919

Aidan M Emery (AM)

London Centre for Neglected Tropical Disease Research (LCNDTR), Imperial College, London, UK.
Wolfson Wellcome Biomedical Laboratories, Natural History Museum, London, UK.
ORCID: 0000-0001-9028-8586

David Rollinson (D)

London Centre for Neglected Tropical Disease Research (LCNDTR), Imperial College, London, UK.
Wolfson Wellcome Biomedical Laboratories, Natural History Museum, London, UK.
ORCID: 0000-0003-1999-1716

Amadou Garba Djirmay (AG)

Réseau International Schistosomiases Environnemental Aménagement et Lutte (RISEAL), Niamey, Niger.
World Health Organization, Geneva, Switzerland.

Khalid M Al Mashikhi (KM)

Directorate General of Health Services, Dhofar Governorate, Salalah, Sultanate of Oman.
ORCID: 0000-0002-9412-6821

Salem Al Yafae (S)

Directorate General of Health Services, Dhofar Governorate, Salalah, Sultanate of Oman.

Mohamed A Idris (MA)

Sultan Qaboos University, Muscat, Sultanate of Oman.
ORCID: 0000-0002-3246-8578

Hélène Moné (H)

Host-Pathogen-Environment Interactions Laboratory, University of Perpignan, Perpignan, France.
ORCID: 0000-0003-3180-344X

Gabriel Mouahid (G)

Host-Pathogen-Environment Interactions Laboratory, University of Perpignan, Perpignan, France.
ORCID: 0000-0003-0332-5081

Philip LoVerde (P)

University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

Jonathan S Marchant (JS)

Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
ORCID: 0000-0001-6592-0877

Timothy J C Anderson (TJC)

Texas Biomedical Research Institute, San Antonio, TX 78227, USA.
ORCID: 0000-0002-0191-0204

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Genetic analysis of praziquantel response in...
Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Anthelminthiques › Genetic analysis of praziquantel response in...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genetic analysis of praziquantel response in...
Recherchemedicale.com › Eucaryotes › Animaux › Invertébrés › Parasites › Genetic analysis of praziquantel response in...
Recherchemedicale.com › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Isoquinoléines › Praziquantel › Genetic analysis of praziquantel response in...
Recherchemedicale.com › Infection › Maladies vectorielles › Schistosomiase › Schistosomiase à Schistosoma mansoni › Genetic analysis of praziquantel response in...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux cationiques TRP › Genetic analysis of praziquantel response in...