Association of Melanoma-Risk Variants with Primary Melanoma Tumor Prognostic Characteristics and Melanoma-Specific Survival in the GEM Study.

Breslow thickness melanoma mitoses single nucleotide polymorphism survival tumor-infiltrating lymphocytes ulceration

Journal

Current oncology (Toronto, Ont.)
ISSN: 1718-7729
Titre abrégé: Curr Oncol
Pays: Switzerland
ID NLM: 9502503

Informations de publication

Date de publication:
16 11 2021
Historique:
received: 11 08 2021
revised: 11 10 2021
accepted: 10 11 2021
entrez: 13 12 2021
pubmed: 14 12 2021
medline: 24 3 2022
Statut: epublish

Résumé

Genome-wide association studies (GWAS) and candidate pathway studies have identified low-penetrant genetic variants associated with cutaneous melanoma. We investigated the association of melanoma-risk variants with primary melanoma tumor prognostic characteristics and melanoma-specific survival. The Genes, Environment, and Melanoma Study enrolled 3285 European origin participants with incident invasive primary melanoma. For each of 47 melanoma-risk single nucleotide polymorphisms (SNPs), we used linear and logistic regression modeling to estimate, respectively, the per allele mean changes in log of Breslow thickness and odds ratios for presence of ulceration, mitoses, and tumor-infiltrating lymphocytes (TILs). We also used Cox proportional hazards regression modeling to estimate the per allele hazard ratios for melanoma-specific survival. Passing the false discovery threshold (

Identifiants

pubmed: 34898573
pii: curroncol28060401
doi: 10.3390/curroncol28060401
pmc: PMC8628692
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4756-4771

Subventions

Organisme : NCI NIH HHS
ID : U01 CA083180
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA233524
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008169
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016086
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA206980
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA098438
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA112243
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA173806
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA112524
Pays : United States
Organisme : NCI NIH HHS
ID : R03 CA125829
Pays : United States

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Auteurs

Danielle R Davari (DR)

Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA.

Irene Orlow (I)

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Peter A Kanetsky (PA)

Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

Li Luo (L)

Department of Internal Medicine, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, NM 87102, USA.

Klaus J Busam (KJ)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Ajay Sharma (A)

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Anne Kricker (A)

Sydney School of Public Health, The University of Sydney, Sydney, NSW 2006, Australia.

Anne E Cust (AE)

Daffodil Centre, The University of Sydney, a Joint Venture with Cancer Council NSW, Sydney, NSW 2006, Australia.
Melanoma Institute Australia, The University of Sydney, Sydney, NSW 2065, Australia.

Hoda Anton-Culver (H)

Department of Medicine, University of California, Irvine, CA 92697, USA.

Stephen B Gruber (SB)

City of Hope National Medical Center, Duarte, CA 91010, USA.

Richard P Gallagher (RP)

BC Cancer and Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC V5Z 1L3, Canada.

Roberto Zanetti (R)

Piedmont Cancer Registry, Centre for Epidemiology and Prevention in Oncology in Piedmont, 10156 Turin, Italy.

Stefano Rosso (S)

Piedmont Cancer Registry, Centre for Epidemiology and Prevention in Oncology in Piedmont, 10156 Turin, Italy.

Lidia Sacchetto (L)

Piedmont Cancer Registry, Centre for Epidemiology and Prevention in Oncology in Piedmont, 10156 Turin, Italy.

Terence Dwyer (T)

Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia.
The Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford OX3 9DU, UK.
Department of Pediatrics, University of Melbourne, Melbourne, VIC 3010, Australia.
Oxford Martin School, University of Oxford, Oxford OX1 3BD, UK.

David C Gibbs (DC)

School of Medicine, Emory University, Atlanta, GA 30322, USA.

David W Ollila (DW)

Department of Surgery, University of North Carolina, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

Colin B Begg (CB)

Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Marianne Berwick (M)

Department of Internal Medicine, University of New Mexico Cancer Center, University of New Mexico, Albuquerque, NM 87102, USA.

Nancy E Thomas (NE)

Department of Dermatology, University of North Carolina, Chapel Hill, NC 27599, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.

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