Electrophoretic Determination of Trimethylamine (TMA) in Biological Samples as a Novel Potential Biomarker of Cardiovascular Diseases Methodological Approach.
biomarkers
capillary electrophoresis (CE)
cardiovascular diseases in athletes
determination of trimethylamine (TMA)
Journal
International journal of environmental research and public health
ISSN: 1660-4601
Titre abrégé: Int J Environ Res Public Health
Pays: Switzerland
ID NLM: 101238455
Informations de publication
Date de publication:
23 11 2021
23 11 2021
Historique:
received:
14
09
2021
revised:
05
11
2021
accepted:
10
11
2021
entrez:
10
12
2021
pubmed:
11
12
2021
medline:
31
12
2021
Statut:
epublish
Résumé
In competitive athletes, the differential diagnosis between nonpathological changes in cardiac morphology associated with training (commonly referred to as "athlete's heart") and certain cardiac diseases with the potential for sudden death is an important and not uncommon clinical problem. The use of noninvasive, fast, and cheap analytical techniques can help in making diagnostic differentiation and planning subsequent clinical strategies. Recent studies have demonstrated the role of gut microbiota and their metabolites in the onset and the development of cardiovascular diseases. Trimethylamine (TMA), a gut bacteria metabolite consisting of carnitine and choline, has recently emerged as a potentially toxic molecule to the circulatory system. The present work aims to develop a simple and cost-effective capillary electrophoresis-based method for the determination of TMA in biological samples. Analytical characteristics of the proposed method were evaluated through the study of its linearity (R
Identifiants
pubmed: 34886043
pii: ijerph182312318
doi: 10.3390/ijerph182312318
pmc: PMC8656779
pii:
doi:
Substances chimiques
Biomarkers
0
Methylamines
0
trimethylamine
LHH7G8O305
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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