Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients.

COVID-19 / mortality Calcifediol / therapeutic use Female Humans Kaplan-Meier Estimate Male Retrospective Studies Spain / epidemiology Survival Analysis Vitamin D / therapeutic use

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
03 12 2021
Historique:
received: 03 09 2021
accepted: 19 11 2021
entrez: 4 12 2021
pubmed: 5 12 2021
medline: 15 12 2021
Statut: epublish

Résumé

COVID-19 is a major worldwide health problem because of acute respiratory distress syndrome, and mortality. Several lines of evidence have suggested a relationship between the vitamin D endocrine system and severity of COVID-19. We present a survival study on a retrospective cohort of 15,968 patients, comprising all COVID-19 patients hospitalized in Andalusia between January and November 2020. Based on a central registry of electronic health records (the Andalusian Population Health Database, BPS), prescription of vitamin D or its metabolites within 15-30 days before hospitalization were recorded. The effect of prescription of vitamin D (metabolites) for other indication previous to the hospitalization was studied with respect to patient survival. Kaplan-Meier survival curves and hazard ratios support an association between prescription of these metabolites and patient survival. Such association was stronger for calcifediol (Hazard Ratio, HR = 0.67, with 95% confidence interval, CI, of [0.50-0.91]) than for cholecalciferol (HR = 0.75, with 95% CI of [0.61-0.91]), when prescribed 15 days prior hospitalization. Although the relation is maintained, there is a general decrease of this effect when a longer period of 30 days prior hospitalization is considered (calcifediol HR = 0.73, with 95% CI [0.57-0.95] and cholecalciferol HR = 0.88, with 95% CI [0.75, 1.03]), suggesting that association was stronger when the prescription was closer to the hospitalization.

Identifiants

DOI: 10.1038/s41598-021-02701-5 PMID: 34862422 PMC: PMC8642445
pubmed: 34862422
doi: 10.1038/s41598-021-02701-5
pii: 10.1038/s41598-021-02701-5
pmc: PMC8642445
doi:

Substances chimiques

Vitamin D 1406-16-2
Calcifediol P6YZ13C99Q

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

23380

Subventions

Organisme : Consejería de Transformación Económica, Industria, Conocimiento y Universidades, Junta de Andalucía
ID : PAIDI2020-DOC_00350
Organisme : Centro de Investigación Biomédica en Red sobre Enfermedades Raras
ID : ACCI2018/29
Organisme : Ministerio de Ciencia e Innovación
ID : PID2020-117979RB-I00
Organisme : Instituto de Salud Carlos III
ID : IMP/0019
Organisme : Instituto de Salud Carlos III
ID : PI19/00033
Organisme : Fundación BBVA
ID : G999088Q
Organisme : H2020 Marie Skłodowska-Curie Actions
ID : 813533
Organisme : Consejería de Salud y Familias, Junta de Andalucía
ID : COVID-011-2020
Organisme : Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable
ID : CB16/10/00245

Informations de copyright

© 2021. The Author(s).

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Auteurs

Carlos Loucera (C)

Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, 41013, Seville, Spain.
Institute of Biomedicine of Seville (IBIS), Hospital Virgen del Rocio, 41013, Seville, Spain.

María Peña-Chilet (M)

Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, 41013, Seville, Spain.
Institute of Biomedicine of Seville (IBIS), Hospital Virgen del Rocio, 41013, Seville, Spain.
Bioinformatics in Rare Diseases (BiER), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), FPS, Hospital Virgen del Rocio, 41013, Seville, Spain.

Marina Esteban-Medina (M)

Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, 41013, Seville, Spain.
Institute of Biomedicine of Seville (IBIS), Hospital Virgen del Rocio, 41013, Seville, Spain.

Dolores Muñoyerro-Muñiz (D)

Subdirección Técnica Asesora de Gestión de la Información, Servicio Andaluz de Salud, Seville, Spain.

Román Villegas (R)

Subdirección Técnica Asesora de Gestión de la Información, Servicio Andaluz de Salud, Seville, Spain.

Jose Lopez-Miranda (J)

Internal Medicine Department, IMIBIC/Reina Sofia University Hospital/University of Cordoba, 14004, Córdoba, Spain.
CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, 28029, Madrid, Spain.

Jesus Rodriguez-Baño (J)

Institute of Biomedicine of Seville (IBIS), Hospital Virgen del Rocio, 41013, Seville, Spain.
Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena, Seville, Spain.
Departamento de Medicina, Universidad de Sevilla, Seville, Spain.

Isaac Túnez (I)

Departamento de Bioquimica y Biología Molecular, Facultad de Medicina y Enfermería, Universidad de Córdoba, Córdoba, Spain.
Instituto Maimónides de Investigacion Biomédica de Córdoba (IMIBIC), 14004, Córdoba, Spain.
G. Técnico de Expertos de Andalucía para Estudios de Suplementos e Intervención Nutricional Frente a Covid-19, SGIDIS, Consejería de Salud y Familias, Junta de Andalucia, Seville, Spain.
Secretaria General de Investigación, Desarrollo e Innovación en Salud, Consejería de Salud y Familias de la Junta de Andalucía, Seville, Spain.

Roger Bouillon (R)

Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KULeuven, Herestraat, 3000, Leuven, Belgium.

Joaquin Dopazo (J)

Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, 41013, Seville, Spain. joaquin.dopazo@juntadeandalucia.es.
Institute of Biomedicine of Seville (IBIS), Hospital Virgen del Rocio, 41013, Seville, Spain. joaquin.dopazo@juntadeandalucia.es.
Bioinformatics in Rare Diseases (BiER), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), FPS, Hospital Virgen del Rocio, 41013, Seville, Spain. joaquin.dopazo@juntadeandalucia.es.
FPS/ELIXIR-ES, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, 41013, Seville, Spain. joaquin.dopazo@juntadeandalucia.es.

Jose Manuel Quesada Gomez (JM)

Instituto Maimónides de Investigacion Biomédica de Córdoba (IMIBIC), 14004, Córdoba, Spain. jmquesada@uco.es.
CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Hospital Universitario Reina Sofía, Universidad de Córdoba, Menéndez Pidal s/n, 14004, Córdoba, Spain. jmquesada@uco.es.

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Classifications MeSH

Recherchemedicale.com › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Real world evidence of calcifediol or vitamin...
Recherchemedicale.com › Lipides › Lipides membranaires › Stérols › Cholécalciférol › Hydroxycholécalciférols › Calcifédiol › Real world evidence of calcifediol or vitamin...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Real world evidence of calcifediol or vitamin...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Estimation de Kaplan-Meier › Real world evidence of calcifediol or vitamin...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Real world evidence of calcifediol or vitamin...
Recherchemedicale.com › Régions géographiques › Europe › Espagne › Real world evidence of calcifediol or vitamin...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Real world evidence of calcifediol or vitamin...
Recherchemedicale.com › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Sécostéroïdes › Vitamine D › Real world evidence of calcifediol or vitamin...