Identification and
Pediatric leukemia
cancer vaccine
high risk T-ALL
neoantigen peptide
pediatric immunotherapy
Journal
Human vaccines & immunotherapeutics
ISSN: 2164-554X
Titre abrégé: Hum Vaccin Immunother
Pays: United States
ID NLM: 101572652
Informations de publication
Date de publication:
02 12 2021
02 12 2021
Historique:
pubmed:
1
12
2021
medline:
19
4
2022
entrez:
30
11
2021
Statut:
ppublish
Résumé
There is experimental and clinical data to indicate the contribution of immune-escape mechanisms in relapsed/refractory pediatric leukemia. Studies have shown the accumulation of mutations that translate to peptides containing tumor-specific epitopes (neoantigens). The effectiveness of neoantigen-based vaccines has been shown in several clinical trials in adults. Though the initial results are encouraging, this knowledge must be developed to account for the uniqueness of pediatric cancer biology. We have completed the initial proof-of-concept analysis on a high-risk pediatric leukemia specimen and identified usable neoantigen sequences. We describe this approach, including the bioinformatics method and experimental model to verify their function that can be further broadened for personalized neoantigen prediction and testing for the generation of anticancer vaccines against high-risk pediatric leukemias.
Identifiants
pubmed: 34844524
doi: 10.1080/21645515.2021.2001243
pmc: PMC8904024
doi:
Substances chimiques
Antigens, Neoplasm
0
Cancer Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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