Blocking IAg
Major histocompatibility complex
NOD mouse
Sjögren's syndrome
Small molecules
Therapy
Journal
Life sciences
ISSN: 1879-0631
Titre abrégé: Life Sci
Pays: Netherlands
ID NLM: 0375521
Informations de publication
Date de publication:
01 Jan 2022
01 Jan 2022
Historique:
received:
09
09
2021
revised:
16
11
2021
accepted:
22
11
2021
pubmed:
30
11
2021
medline:
11
1
2022
entrez:
29
11
2021
Statut:
ppublish
Résumé
Sjögren's syndrome (SjS) is an autoimmune disease with a strong genetic association. To date, no vaccine or therapeutic agent exists to cure SjS, and patients must rely on lifelong therapies to treat symptoms. Human leukocyte antigens (HLA) are primary susceptibility loci that form the genetic basis for many autoimmune diseases, including SjS. In this study, we sought to determine whether blocking MHC class II IAg Mapping of the antigenic epitopes of Ro60 autoantigen to IAg Specific peptides of Ro60 autoantigen were identified to bind to IAg This study presents a novel therapeutic approach for SjS by identifying small molecules capable of inhibiting T cell response via antigen-specific presentation. CQN is supported financially in part by PHS grants AI130561, DE026450, and DE028544 from the National Institutes of Health.
Sections du résumé
BACKGROUND
BACKGROUND
Sjögren's syndrome (SjS) is an autoimmune disease with a strong genetic association. To date, no vaccine or therapeutic agent exists to cure SjS, and patients must rely on lifelong therapies to treat symptoms. Human leukocyte antigens (HLA) are primary susceptibility loci that form the genetic basis for many autoimmune diseases, including SjS. In this study, we sought to determine whether blocking MHC class II IAg
METHODS
METHODS
Mapping of the antigenic epitopes of Ro60 autoantigen to IAg
FINDINGS
RESULTS
Specific peptides of Ro60 autoantigen were identified to bind to IAg
INTERPRETATION
CONCLUSIONS
This study presents a novel therapeutic approach for SjS by identifying small molecules capable of inhibiting T cell response via antigen-specific presentation.
FUNDING
BACKGROUND
CQN is supported financially in part by PHS grants AI130561, DE026450, and DE028544 from the National Institutes of Health.
Identifiants
pubmed: 34843735
pii: S0024-3205(21)01169-3
doi: 10.1016/j.lfs.2021.120182
pmc: PMC8883604
mid: NIHMS1780885
pii:
doi:
Substances chimiques
Alkanes
0
Antimetabolites, Antineoplastic
0
Histocompatibility Antigens Class II
0
I-A g7 antigen
0
Polycyclic Compounds
0
Azaguanine
Q150359I72
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
120182Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE026450
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE028544
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI130561
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
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