Correlation between Biophysical Properties of Niosomes Elaborated with Chloroquine and Different Tensioactives and Their Transfection Efficiency.
biophysical properties
chloroquine
gene delivery
niosomes
surfactants
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
26 Oct 2021
26 Oct 2021
Historique:
received:
30
09
2021
revised:
21
10
2021
accepted:
22
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
28
11
2021
Statut:
epublish
Résumé
Lipid nanocarriers, such as niosomes, are considered attractive candidates for non-viral gene delivery due to their suitable biocompatibility and high versatility. In this work, we studied the influence of incorporating chloroquine in niosomes biophysical performance, as well as the effect of non-ionic surfactant composition and protocol of incorporation in their biophysical performance. An exhaustive comparative evaluation of three niosome formulations differing in these parameters was performed, which included the analysis of their thermal stability, rheological behavior, mean particle size, dispersity, zeta potential, morphology, membrane packing capacity, affinity to bind DNA, ability to release and protect the genetic material, buffering capacity and ability to escape from artificially synthesized lysosomes. Finally, in vitro biological studies were, also, performed in order to determine the compatibility of the formulations with biological systems, their transfection efficiency and transgene expression. Results revealed that the incorporation of chloroquine in niosome formulations improved their biophysical properties and the transfection efficiency, while the substitution of one of the non-ionic surfactants and the phase of addition resulted in less biophysical variations. Of note, the present work provides several biophysical parameters and characterization strategies that could be used as gold standard for gene therapy nanosystems evaluation.
Identifiants
pubmed: 34834203
pii: pharmaceutics13111787
doi: 10.3390/pharmaceutics13111787
pmc: PMC8623750
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : University of the Basque Country
ID : PIF17/79
Organisme : University of the Basque Country
ID : ESPDOC19/47
Organisme : Basque Government
ID : Consolidated Groups IT907-16
Organisme : Spanish Ministry of Science and Innovation
ID : PID2019-106199RB-C21
Organisme : Spanish Ministry of Science and Innovation
ID : RTI2018-099985-B-I00
Organisme : Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine
ID : CIBER-BBN
Organisme : Biomedical Research Networking Center of Respiratory Disease
ID : CIBERES-ISCIII
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