MiR-191 as a Key Molecule in Aneurysmal Aortic Remodeling.
abdominal aortic aneurysms
endothelial dysfunction
microRNA
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
30 10 2021
30 10 2021
Historique:
received:
17
08
2021
revised:
01
10
2021
accepted:
05
10
2021
entrez:
27
11
2021
pubmed:
28
11
2021
medline:
13
1
2022
Statut:
epublish
Résumé
Abdominal aortic aneurysms (AAA) are a complex disease with an unclear pathomechanism. A positive family history is emphasized as a significant risk factor, and a nonspecific model of inheritance suggests participation of epigenetic regulation in the pathogenesis of this disease. Past studies have implicated microRNAs in the development of AAA; therefore in this project, we measured miR-191 levels in AAA patients and compared them with a control group. We found that miR-191 levels were significantly elevated in aneurysmal patients, although this did not correlate with the available clinical data. We then developed an in vitro model where, using cells with an endothelial phenotype, we determined the effect of miR-191 on the transcriptome using RNA sequencing. Subsequent pathway analysis established that some of the perturbations mediated by miR-191 can be explained by several processes which have long been observed and described in literature as accompanying the development of abdominal aortic aneurysms.
Identifiants
pubmed: 34827608
pii: biom11111611
doi: 10.3390/biom11111611
pmc: PMC8615628
pii:
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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