Prenatal Exposure to Chemical Mixtures and Inhibition among Adolescents.
adolescent neurodevelopment
chemical mixtures
executive function
inhibition
metals
organochlorines
prenatal exposures
Journal
Toxics
ISSN: 2305-6304
Titre abrégé: Toxics
Pays: Switzerland
ID NLM: 101639637
Informations de publication
Date de publication:
16 Nov 2021
16 Nov 2021
Historique:
received:
11
10
2021
revised:
05
11
2021
accepted:
10
11
2021
entrez:
25
11
2021
pubmed:
26
11
2021
medline:
26
11
2021
Statut:
epublish
Résumé
Inhibition, one of the building blocks of executive function, is the ability to focus one's attention despite interference from external stimuli. It undergoes substantial development during adolescence and may be susceptible to adverse impacts of prenatal exposure to chemical mixtures, yet few studies have explored this association. The New Bedford Cohort (NBC) is a birth cohort of residents living near the New Bedford Harbor Superfund site in Massachusetts. Among adolescents from the NBC, we investigated the association of biomarkers of prenatal exposure to organochlorines (DDE, HCB, PCBs) and metals (Pb, Mn) with inhibition, assessed with the Delis-Kaplan Executive Function System Design Fluency (non-verbal task) and Color-Word Interference (verbal task) subtests. An exploratory mixtures analysis using Bayesian kernel machine regression (BKMR) informed a traditional multivariable regression approach. NBC adolescents are diverse with 29% non-white and 31% in a low-income household at birth. Cord serum organochlorine concentrations and cord blood metals concentrations were generally similar to other birth cohorts. In BKMR models, we observed a suggestive adverse association of the chemical mixture with Color-Word Interference but not Design Fluency. In covariate-adjusted linear regression models including all five chemical exposure measures, a doubling of cord blood Mn was associated with poorer Color-Word Interference completion time scaled scores (difference = -0.74; 95% CI: -1.34, -0.14). This study provided evidence of an adverse joint association between prenatal exposure to a five-chemical mixture and verbal inhibition in adolescence with exposure to Mn potentially driving this overall association.
Identifiants
pubmed: 34822702
pii: toxics9110311
doi: 10.3390/toxics9110311
pmc: PMC8619850
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES000002
Pays : United States
Organisme : ACL HHS
ID : T42OH008416
Pays : United States
Références
Environ Health Perspect. 2012 Jun;120(6):904-9
pubmed: 22357172
Chemosphere. 2016 Nov;163:270-282
pubmed: 27540762
Environ Health Perspect. 2002 Feb;110 Suppl 1:25-42
pubmed: 11834461
Environ Health Perspect. 2012 Apr;120(4):608-15
pubmed: 22142904
Environ Health Perspect. 2005 Oct;113(10):1376-80
pubmed: 16203250
Environ Sci Technol. 2014 Dec 16;48(24):14695-702
pubmed: 25390650
Synapse. 2011 Jun;65(6):532-44
pubmed: 20963817
Environ Health. 2018 Aug 20;17(1):67
pubmed: 30126431
Pharmacol Ther. 2007 Feb;113(2):369-77
pubmed: 17084903
Neurotoxicol Teratol. 2006 Sep-Oct;28(5):536-47
pubmed: 17067778
Environ Health Perspect. 2020 Jan;128(1):17012
pubmed: 31944143
Neurotoxicol Teratol. 2007 Mar-Apr;29(2):181-7
pubmed: 17079114
Neurotoxicology. 2006 Mar;27(2):210-6
pubmed: 16310252
Clin Biochem Rev. 2019 Aug;40(3):115-133
pubmed: 31530963
Environ Health. 2016 Aug 30;15(1):91
pubmed: 27576472
J Expo Anal Environ Epidemiol. 2000 Nov-Dec;10(6 Pt 2):743-54
pubmed: 11138666
Environ Health Perspect. 2014 Nov;122(11):1253-9
pubmed: 25062363
Environ Health Perspect. 2006 Dec;114(12):1923-9
pubmed: 17185286
Lancet. 2006 Dec 16;368(9553):2167-78
pubmed: 17174709
Annu Rev Psychol. 2013;64:135-68
pubmed: 23020641
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2693-8
pubmed: 21262822
Lancet Neurol. 2014 Mar;13(3):330-8
pubmed: 24556010
Environ Health Perspect. 2020 Sep;128(9):97002
pubmed: 32897104
Environ Health Perspect. 1998 Jun;106 Suppl 3:841-7
pubmed: 9646047
Environ Health Perspect. 2003 Oct;111(13):1670-7
pubmed: 14527849
Neurotoxicol Teratol. 2005 Nov-Dec;27(6):771-80
pubmed: 16198536
Environ Health. 2014 Apr 01;13(1):23
pubmed: 24684736
J Pediatr. 2003 Dec;143(6):780-8
pubmed: 14657828
Annu Rev Nutr. 2015;35:71-108
pubmed: 25974698
Neurotoxicology. 2014 Jan;40:16-22
pubmed: 24211492
Crit Rev Toxicol. 2008;38(10):877-93
pubmed: 19012089
Curr Environ Health Rep. 2015 Sep;2(3):284-94
pubmed: 26231505
Neurotoxicology. 2002 Oct;23(4-5):635-43
pubmed: 12428735
Environ Res. 2013 Feb;121:39-44
pubmed: 23141434
Neurotoxicol Teratol. 2017 Jan - Feb;59:35-42
pubmed: 27989696
Environ Health Perspect. 2006 Jul;114(7):1092-8
pubmed: 16835064
Am J Epidemiol. 2017 May 15;185(10):924-932
pubmed: 28444119
Gut. 2012 Nov;61(11):1583-8
pubmed: 22184070
Neurotoxicology. 2014 Dec;45:301-8
pubmed: 24308913
Neurotoxicol Teratol. 2011 Mar-Apr;33(2):205-11
pubmed: 20868742
Environ Health Perspect. 2013 Jan;121(1):A6-8
pubmed: 23409283
Environ Health Perspect. 2003 Jan;111(1):65-70
pubmed: 12515680
Environ Health Perspect. 2004 Aug;112(11):1165-71
pubmed: 15289161
Neurotoxicol Teratol. 1993 Jan-Feb;15(1):27-35
pubmed: 8459785
Neurotoxicology. 2019 Dec;75:105-115
pubmed: 31513824
Environ Int. 2018 Sep;118:304-313
pubmed: 29933234
Environ Int. 2016 Dec;97:204-211
pubmed: 27666324
Environ Int. 2017 Nov;108:299-308
pubmed: 28941415
Epidemiology. 2010 Jul;21(4):433-9
pubmed: 20549838
Am J Epidemiol. 2010 Mar 1;171(5):593-601
pubmed: 20106937
Neurotoxicology. 2011 Aug;32(4):450-7
pubmed: 21453724
Environ Res. 2017 Feb;153:8-16
pubmed: 27880879
Environ Health Perspect. 2015 Jul;123(7):717-22
pubmed: 25734517
PLoS One. 2011;6(12):e28075
pubmed: 22162756