Molecular and phenotypic profiling of colorectal cancer patients in West Africa reveals biological insights.
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Biomarkers, Tumor
/ genetics
Case-Control Studies
Colorectal Neoplasms
/ diagnosis
Female
High-Throughput Nucleotide Sequencing
Humans
Liver Neoplasms
/ epidemiology
Lung Neoplasms
/ epidemiology
Male
Microsatellite Instability
Middle Aged
Mutation
Nigeria
/ epidemiology
Peritoneal Neoplasms
/ epidemiology
Risk Factors
Young Adult
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
24 11 2021
24 11 2021
Historique:
received:
01
09
2020
accepted:
28
10
2021
entrez:
25
11
2021
pubmed:
26
11
2021
medline:
24
12
2021
Statut:
epublish
Résumé
Understanding the molecular and phenotypic profile of colorectal cancer (CRC) in West Africa is vital to addressing the regions rising burden of disease. Tissue from unselected Nigerian patients was analyzed with a multigene, next-generation sequencing assay. The rate of microsatellite instability is significantly higher among Nigerian CRC patients (28.1%) than patients from The Cancer Genome Atlas (TCGA, 14.2%) and Memorial Sloan Kettering Cancer Center (MSKCC, 8.5%, P < 0.001). In microsatellite-stable cases, tumors from Nigerian patients are less likely to have APC mutations (39.1% vs. 76.0% MSKCC P < 0.001) and WNT pathway alterations (47.8% vs. 81.9% MSKCC, P < 0.001); whereas RAS pathway alteration is more prevalent (76.1% vs. 59.6%, P = 0.03). Nigerian CRC patients are also younger and more likely to present with rectal disease (50.8% vs. 33.7% MSKCC, P < 0.001). The findings suggest a unique biology of CRC in Nigeria, which emphasizes the need for regional data to guide diagnostic and treatment approaches for patients in West Africa.
Identifiants
pubmed: 34819518
doi: 10.1038/s41467-021-27106-w
pii: 10.1038/s41467-021-27106-w
pmc: PMC8613248
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6821Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2021. The Author(s).
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