Epicardial adipose tissue volume and myocardial ischemia in asymptomatic people living with diabetes: a cross-sectional study.
Adipose Tissue
/ diagnostic imaging
Adiposity
Aged
Asymptomatic Diseases
Cross-Sectional Studies
Diabetes Mellitus, Type 1
/ diagnostic imaging
Diabetes Mellitus, Type 2
/ diagnostic imaging
Female
France
/ epidemiology
Humans
Male
Middle Aged
Myocardial Ischemia
/ diagnostic imaging
Pericardium
/ diagnostic imaging
Predictive Value of Tests
Retrospective Studies
Risk Assessment
Risk Factors
Tomography, X-Ray Computed
Computed tomography
Coronary artery calcification
Diabetes
Epicardial adipose tissue
Epicardial fat tissue
Myocardial ischemia
Visceral fat
Journal
Cardiovascular diabetology
ISSN: 1475-2840
Titre abrégé: Cardiovasc Diabetol
Pays: England
ID NLM: 101147637
Informations de publication
Date de publication:
24 11 2021
24 11 2021
Historique:
received:
13
09
2021
accepted:
14
11
2021
entrez:
25
11
2021
pubmed:
26
11
2021
medline:
22
2
2022
Statut:
epublish
Résumé
Epicardial adipose tissue (EAT) is considered a novel diagnostic marker for cardiometabolic disease. This study aimed to evaluate whether EAT volume was associated with stress-induced myocardial ischemia in asymptomatic people living with diabetes-independently of confounding factors-and whether it could predict this condition. We included asymptomatic patients with diabetes and no coronary history, who had undergone both a stress a myocardial scintigraphy to diagnose myocardial ischemia, and a computed tomography to measure their coronary artery calcium (CAC) score. EAT volume was retrospectively measured from computed tomography imaging. Determinants of EAT volume and asymptomatic myocardial ischemia were evaluated. The study population comprised 274 individuals, including 153 men. Mean (± standard deviation) age was 62 ± 9 years, and 243, 23 and 8 had type 2, type 1, or another type of diabetes, respectively. Mean body mass index was 30 ± 6 kg/m EAT may play a role in coronary atherosclerosis and coronary circulation in patients with diabetes. However, considering EAT volume is not a better marker for discriminating the risk of asymptomatic myocardial ischemia than classic clinical data.
Sections du résumé
BACKGROUND
Epicardial adipose tissue (EAT) is considered a novel diagnostic marker for cardiometabolic disease. This study aimed to evaluate whether EAT volume was associated with stress-induced myocardial ischemia in asymptomatic people living with diabetes-independently of confounding factors-and whether it could predict this condition.
METHODS
We included asymptomatic patients with diabetes and no coronary history, who had undergone both a stress a myocardial scintigraphy to diagnose myocardial ischemia, and a computed tomography to measure their coronary artery calcium (CAC) score. EAT volume was retrospectively measured from computed tomography imaging. Determinants of EAT volume and asymptomatic myocardial ischemia were evaluated.
RESULTS
The study population comprised 274 individuals, including 153 men. Mean (± standard deviation) age was 62 ± 9 years, and 243, 23 and 8 had type 2, type 1, or another type of diabetes, respectively. Mean body mass index was 30 ± 6 kg/m
CONCLUSIONS
EAT may play a role in coronary atherosclerosis and coronary circulation in patients with diabetes. However, considering EAT volume is not a better marker for discriminating the risk of asymptomatic myocardial ischemia than classic clinical data.
Identifiants
pubmed: 34819079
doi: 10.1186/s12933-021-01420-5
pii: 10.1186/s12933-021-01420-5
pmc: PMC8613918
doi:
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
224Informations de copyright
© 2021. The Author(s).
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