Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis.
Alzheimer’s disease
amyloid
hippocampus
oligomers
synaptic pathology
transgenic mice (Tg)
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2021
2021
Historique:
received:
03
08
2021
accepted:
04
10
2021
entrez:
22
11
2021
pubmed:
23
11
2021
medline:
23
11
2021
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by initial memory impairments that progress to dementia. In this sense, synaptic dysfunction and loss have been established as the pathological features that best correlate with the typical early cognitive decline in this disease. At the histopathological level,
Identifiants
pubmed: 34803589
doi: 10.3389/fnins.2021.752594
pmc: PMC8600261
doi:
Types de publication
Journal Article
Langues
eng
Pagination
752594Informations de copyright
Copyright © 2021 Sanchez-Varo, Sanchez-Mejias, Fernandez-Valenzuela, De Castro, Mejias-Ortega, Gomez-Arboledas, Jimenez, Sanchez-Mico, Trujillo-Estrada, Moreno-Gonzalez, Baglietto-Vargas, Vizuete, Davila, Vitorica and Gutierrez.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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