BST1 regulates nicotinamide riboside metabolism via its glycohydrolase and base-exchange activities.

A549 Cells ADP-ribosyl Cyclase / genetics Administration, Oral Aging / drug effects Animals Antigens, CD / genetics Dietary Supplements GPI-Linked Proteins / genetics Gastrointestinal Microbiome Glycoside Hydrolases / genetics Humans Intestinal Mucosa / metabolism Intestine, Small / metabolism Mice Mice, Knockout Niacin / metabolism Niacinamide / administration & dosage Pentosyltransferases / genetics Pyridinium Compounds / administration & dosage

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
19 11 2021
Historique:
received: 11 12 2020
accepted: 04 11 2021
entrez: 20 11 2021
pubmed: 21 11 2021
medline: 24 12 2021
Statut: epublish

Résumé

Nicotinamide riboside (NR) is one of the orally bioavailable NAD

Identifiants

DOI: 10.1038/s41467-021-27080-3 PMID: 34799586 PMC: PMC8604996
pubmed: 34799586
doi: 10.1038/s41467-021-27080-3
pii: 10.1038/s41467-021-27080-3
pmc: PMC8604996
doi:

Substances chimiques

Antigens, CD 0
GPI-Linked Proteins 0
Pyridinium Compounds 0
nicotinamide-beta-riboside 0I8H2M0L7N
Niacinamide 25X51I8RD4
Niacin 2679MF687A
Pentosyltransferases EC 2.4.2.-
Glycoside Hydrolases EC 3.2.1.-
ADP-ribosyl Cyclase EC 3.2.2.5
ADP-ribosyl cyclase 2 EC 3.2.2.5
nicotinate phosphoribosyltransferase EC 6.3.4.21

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6767

Informations de copyright

© 2021. The Author(s).

Références

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Auteurs

Keisuke Yaku (K)

Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.

Sailesh Palikhe (S)

Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.

Hironori Izumi (H)

Department of Molecular Neuroscience, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
Research Center for Idling Brain Science (RCIBS), University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.

Tomoyuki Yoshida (T)

Department of Molecular Neuroscience, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
Research Center for Idling Brain Science (RCIBS), University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
ORCID: 0000-0002-8476-3798

Keisuke Hikosaka (K)

Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.

Faisal Hayat (F)

Mitchell Cancer Institute, Department of Pharmacology, University of South Alabama, 1660 Springhill Avenue, Mobile, AL, 36693, USA.

Mariam Karim (M)

Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.

Tooba Iqbal (T)

Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.

Yasuhito Nitta (Y)

Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.

Atsushi Sato (A)

School of Bioscience and Biotechnology, Tokyo University of Technology, 1404-1 Katakuramachi, Hachioji, Tokyo, 192-0982, Japan.

Marie E Migaud (ME)

Mitchell Cancer Institute, Department of Pharmacology, University of South Alabama, 1660 Springhill Avenue, Mobile, AL, 36693, USA.

Katsuhiko Ishihara (K)

Department of Immunology and Molecular Genetics, Kawasaki Medical University, 577 Matsushima, Kurashiki, Okayama, 701-0192, Japan.
ORCID: 0000-0002-2826-5188

Hisashi Mori (H)

Department of Molecular Neuroscience, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
Research Center for Idling Brain Science (RCIBS), University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
Research Center for Pre-Disease Science, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan.
ORCID: 0000-0001-9743-2456

Takashi Nakagawa (T)

Department of Molecular and Medical Pharmacology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan. nakagawa@med.u-toyama.ac.jp.
Research Center for Pre-Disease Science, University of Toyama, 2630 Sugitani, Toyama, Toyama, 930-0194, Japan. nakagawa@med.u-toyama.ac.jp.
ORCID: 0000-0001-5539-7605

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Classifications MeSH

Recherchemedicale.com › Cellules › Cellules épithéliales › Cellules A549 › BST1 regulates nicotinamide riboside...
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › ADP ribose transferases › NAD nucleosidase › ADP-ribosyl cyclase › BST1 regulates nicotinamide riboside...
Recherchemedicale.com › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › BST1 regulates nicotinamide riboside...
Recherchemedicale.com › Phénomènes physiologiques › Croissance et développement › Vieillissement › BST1 regulates nicotinamide riboside...
Recherchemedicale.com › Eucaryotes › Animaux › BST1 regulates nicotinamide riboside...
Recherchemedicale.com › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes CD › BST1 regulates nicotinamide riboside...
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Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Protéines liées au GPI › BST1 regulates nicotinamide riboside...
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Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › BST1 regulates nicotinamide riboside...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › BST1 regulates nicotinamide riboside...
Recherchemedicale.com › Tissus › Membranes › Muqueuse › Muqueuse intestinale › BST1 regulates nicotinamide riboside...
Recherchemedicale.com › Système digestif › Tube digestif › Intestins › Intestin grêle › BST1 regulates nicotinamide riboside...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › BST1 regulates nicotinamide riboside...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › BST1 regulates nicotinamide riboside...
Recherchemedicale.com › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides nicotiniques › Acide nicotinique › BST1 regulates nicotinamide riboside...
Recherchemedicale.com › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Acides nicotiniques › Nicotinamide › BST1 regulates nicotinamide riboside...
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Pentosyltransferases › BST1 regulates nicotinamide riboside...
Recherchemedicale.com › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Composés de pyridinium › BST1 regulates nicotinamide riboside...