A Web Portal for Communicating Polygenic Risk Score Results for Health Care Use-The P5 Study.
P5 study
coronary heart disease
finhealth 2017 study
polygenic risk sore
precision population health
type 2 diabetes
venous thromboembolism
web portal
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2021
2021
Historique:
received:
23
08
2021
accepted:
18
10
2021
entrez:
15
11
2021
pubmed:
16
11
2021
medline:
16
11
2021
Statut:
epublish
Résumé
We present a method for communicating personalized genetic risk information to citizens and their physicians using a secure web portal. We apply the method for 3,177 Finnish individuals in the P5 Study where estimates of genetic and absolute risk, based on genetic and clinical risk factors, of future disease are reported to study participants, allowing individuals to participate in managing their own health. Our method facilitates using polygenic risk score as a personalized tool to estimate a person's future disease risk while offering a way for health care professionals to utilize the polygenic risk scores as a preventive tool in patient care.
Identifiants
pubmed: 34777479
doi: 10.3389/fgene.2021.763159
pii: 763159
pmc: PMC8585790
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
763159Informations de copyright
Copyright © 2021 Marjonen, Marttila, Paajanen, Vornanen, Brunfeldt, Joensuu, Halmesvaara, Aro, Alanne-Kinnunen, Jousilahti, Borodulin, Koskinen, Tuomi, Ilanne-Parikka, Lindström, Laine, Auro, Kääriäinen, Perola and Kristiansson.
Déclaration de conflit d'intérêts
Authors KAu and KAr were employed by the company Negen Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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